Biopolym. Cell. 2018; 34(3):171-195.
Огляди
Клітинні та неклітинні технології у лікуванні незагоювальних ран
1Орловська І. В., 1Яковенко І. О., 1Гайдак А. Х., 2Змейкоскі Д. З., 1Козировська Н. О.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03143
  2. Вінчеський інститут ядерних наук, Белградський університет
    12-14, вул. Майка Петровича, Белград, Сербія

Abstract

Сучасна терапія регенеративної медицини інспірована досягненнями у галузі клітинної біології, генної інженерії, синтетичної біології, матеріалознавства, довершує традиційну терапію, що робить можливим лікування хронічних недуг. У наш час лікування хронічних ран можливе через використання клітинних регенеративних технологій та більш пізніх неклітинних терапевтичних підходів. В огляді ми розглядаємо альтернативні підходи до лікування незагоювальних ран за допомогою клінічного застосування стовбурових клітин, а також клітинних та тканинних продуктів. Для клітинних технологій регенерації тканин та біоінженерії використовують стовбурові клітини, які вводяться в кров'яне русло або безпосередньо у рану. Інший підхід грунтується на регенераційних неклітинних технологіях, які потребують продукти стовбурових клітин, тобто, секретоми або їхні окремі компоненти - позаклітинні мембранні везикули, а також тканинні продукти. Технологія стовбурових клітин призначена для заміни критично відсутніх компонентів поранених або дегенеративних тканин. Секретом стовбурових клітин незалежно від стовбурових клітин може сприяти відновленню пошкоджених тканин. Позаклітинні мембранні везикули здатні імітувати механізми стовбурових клітин в процесі регенерації тканин і, отже, є переспективними у лікуванні хронічних ран та ускладнених опіків. Тканинні продукти традиційно залишаються ефективними засобоми загоювання ран на тлі сучасних технологій.
Keywords: загоєння ран, клітинні і неклітинні технології, стовбурові клітини, cекретоми, позаклітинні мембранні везикули, тканинні продукти

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