Регуляція мінливості геному соматичних клітин ссавців під впливом екзогенних біологічних чинників

Лукаш, Л. Л.

doi:10.7124/bc.000697

Biopolym. Cell. 2004; 20(1-2):93-105.

http://dx.doi.org/10.7124/bc.000697

Регуляція мінливості геному соматичних клітин ссавців під впливом екзогенних біологічних чинників

1Лукаш Л. Л.

Інститут молекулярної біології і генетики НАН України
Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Проаналізовано результати досліджень, які демонструють, що біологічні чинники довкілля здатні індукувати мутації, здійснюючи при цьому регуляторно-інформаційний вплив на клітинні системи підтримання генетичної стабільності: реплікацію, рекомбінацію, репарацію. Серед біологічних факторів, що дестабілізують клітинний геном, особливо виокремлюються мобільні генетичні елементи та онкогенні віруси, які спричиняють злоякісну трансформацію клітин. Висловлено припущення стосовно того, що зміна програм генної експресії при диференціюванні стовбурових клітин у спеціалізовані супроводжується запуском процесів мутаційної і рекомбінаційної мінливості

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