Biopolym. Cell. 1997; 13(1):46-54.
http://dx.doi.org/10.7124/bc.000466
Структура та функції біополімерів
Вивчення стабільності уотсон-криківських пар основ нуклеїнових кислот у воді та диметилсульфоксиді: комп'ютерне моделювання методом Монте-Карло
1Данілов В. І., 1Желтовський М. В., 1Слюсарчук О. М., 2Альдерфер Дж. Л.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680
  2. Раковий інститут ім. Розвелл Парк
    вул. Елм і Карлтон, Баффало, Нью-Йорк, США, 14 263

Abstract

Проведено екстенсивне комп'ютерне моделювання основ нук­леїнових кислот і уотсон-криківських пар у воді та ДМСО методом Монте-Карло. Виявлено, що енергетична невигід­ність утворення пар у воді зумовлена значним дестабілі­зуючим внеском розчинника в ентальпію утворення комп­лексів. Показано, що у ДМСО утворення копланарних пар вигідно. Цей розчинник стабілізує пари A-U і А-Т, а незначна дестабілізація цим розчинником пари G-C значно менша, ніж стабілізація, пов'язана з притягненням між основами.
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