Biopolym. Cell. 1985; 1(6):293-307.
Огляди
Нові інгібітори біосинтезу ДНК і РНК in vitro і in vivo
1Бібілашвілі Р. Ш., 1Чіджавадзе З. Г., 2Краєвський А. А., 2Куханова М. К., 2Атражев А. М., 3Ажаєв А. В., 2Кутателадзе Т. В.
- Інститут експериментальної кардіології, Всесоюзного кардіологічного наукового центру АМН СРСР
Москва, СРСР - Інститут молекулярної біології АН СРСР
Москва, СРСР - Інститут фізіології АН Грузинської РСР
Тбілісі, СРСР
Abstract
Огляд власних даних авторів щодо способів синтезу і властивостей великої кількості нових інгібіторів біосинтезу ДНК і РНК in vitro і in vivo. На індивідуальних матрицях за участі очищених ДНК- і РНК-полімераз визначено молекулярний механізм дії цих інгібіторів у реакціях полімеризації, пірофосфоролізу і гідролізу. Показано застосовність деяких інгібіторів для вивчення реплікації в культурі клітин еукаріотів, в ембріонах і ядрах клітин, а також репарації ДНК у хроматині.
Повний текст: (PDF, російською)
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