Biopolym. Cell. 1988; 4(4):182-187.
Structure and Function of Biopolymers
Structure and properties of poly(dA) ·poIy(dT) and A : T sites in DNA. Calculations of the energy of nonvalent interactions in the system consisting of a regular polynucleotide and two hydration shells in its minor groove
1Golovinskaya A. G., 2Poltev V. I., 1Chuprina V. P.
  1. Research Computer Center, Academy of Sciences of USSR
    Pushchino, Moscow Region, USSR
  2. Institute of Biological Physics, Academy of Sciences of the USSR
    Pushchino, Moscow Region, USSR


Interaction of poly(dA)·poly(dT) with two hydration shells forming a hydration spine similar to that found in the central part of the double-helical fragment d(CGCGAATTCGCG) in crystal to a considerable extent determines the existence of a specific polynucleotide conformation in fibers and in solutions. Atom-molecular models of these conformations with a narrow minor groove, a negative tilt and a positive propeller of the bases have been proposed. They explain a number of experimental facts concerning biologically important structural properties of DNA.


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