Biopolym. Cell. 2014; 30(6):477-480.
Biomedicine
Association between the PSMB5 and PSMC6 genetic variations and children obesity in the Latvian population
1Paramonova N., 2, 3Kupca S., 2, 3Rumba-Rozenfelde I., 2, 4Sjakste N., 1Sjakste T.
  1. Genomics and Bioinformatics, Institute of Biology
    University of Latvia
    3, Miera Str., Salaspils, Latvia, LV-2169
  2. Faculty of Medicine,
    University of Latvia
    19, Raina blvd., Riga, Latvia, LV-1586
  3. University Children Hospital
    20, Juglas Str., Riga, Latvia, LV-1079
  4. Latvian Institute of Organic Synthesis
    21, Aizkraukles Str., Riga, Latvia, LV-1006

Abstract

According to the recent data the ubiquitin-proteasome system (UPS) is implicated in the pathogenesis of obesity. Aim of our study was to evaluate a possible association between genetic variations in the PSMB5 and PSMC6 genes and childhood obesity in the Latvian population. Methods. The rs11543947 (PSMB5), rs2295826 and rs2295827 (PSMC6) were genotyped in 94 overweight children versus 191 controls. Stratification was made by family history and sex. Results. Heterozygous genotype at rs11543947 (PSMB5) manifested association with the disease (P < 0.01) in total group and in patients with family history (OR = 2.445 [95 % CI 1.378–4.339] and OR = 2.746 [95 % CI 1.427–5.283], respectively). This genotype was observed more frequently (P < 0.05) in males with family obesity and in females without family history (P < 0.01).The heterozygotes at rs2295826 and rs2295827 showed association (P < 0.01) in obesity (OB), in patients with family history (OR = 2.119 [95 % CI 1.207–3.718] and OR = 2.379 [95 % CI 1.249–4.533], respectively) and in males group. The rs11543947/ rs2295826-rs2295827 multi locus genotype heterozygous at all the studied loci and the haplotype represented by the rare alleles were more frequent in obese children when compared to controls (P < 0.001 and P = 0.0001 respectively). Conclusions. Genetic variations of the PSMB5 (rs11543947) and PSMC6 (rs2295826 and rs2295827) genes can influence childhood obesity in Latvians.
Keywords: PSMB5, PSMC6, SNPs, obesity, familial obesity, genotype–sex interaction.

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