Biopolym. Cell. 1985; 1(1):5-13.
Structure and Function of Biopolymers
B–A transition in DNA and transcription
1Ivanov V. I.
  1. Institute of Molecular Biology, Academy of Sciences of the USSR
    Moscow, USSR


The paper deals with the current progress in elucidation of the significance of the A form of DNA in transcription and its regulation. The three aspects are considered: (1) the B–A transition during RNA polymerase operation, (2) the studies on the physics of the B–A transition with the aim to obtain thermodynamic parameters of this transformation and such properties as sequence effect which might be indicative of the possibility for an active role of the B–A transition in gene regulation, (3) a conformational hypothesis on the operation mechanism for the activator of bacterial operons, the CAP protein.


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