The high scale screening of confounds of the series of isoflavonoids and 4-phenylcoumarins with the use of microorganisms

Authors

  • A. M. Zhyvoloup Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author
  • S. M. Yarmoluk Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author
  • M. M. Garazd Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author
  • Y. L. Garazd Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine 1, Murmans'ka Str., Kyiv, Ukraine, 02094 Author
  • V. V. Shylin Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine 1, Murmans'ka Str., Kyiv, Ukraine, 02094 Author
  • A. S. Ogorodniychuk Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine 1, Murmans'ka Str., Kyiv, Ukraine, 02094 Author
  • V. P. Khyla Taras Shevchenko National University of Kyiv 64, Volodymyrska Str., Kyiv, Ukraine, 01033 Author

DOI:

https://doi.org/10.7124/bc.0004FA

Abstract

In order to investigate antimicrobial activity of more then 300 compounds of the series of isoflavonoids and 4-phenylcoumarins Salmonella typhimurium LT.2, Escherichia coli and Candida albicans were used. Two structural chemical fragments 7-(1-R1-2-R2-1-on-ethyl)-O-4-phenylcoumarin and 2-R4-3-R5-6-R2-8-R3-7-R1 O- chromone possessing antibactericidal and anticandidal effects were determined.

References

Hogan JC Jr. Combinatorial chemistry in drug discovery. Nat Biotechnol. 1997;15(4):328-30.

Ferguson AM. Designing Chemical Libraries for Lead Discovery. J Biomol Screen. 1996;1(2):65–73.

Klein RD. Recombinant Microorganisms as Tools for High Throughput Screening for Nonantibiotic Compounds. J Biomol Screen. 1997;2(1):41–9.

Kazakov A, Khilya VP, Mezheretskiy VV, Yashyken D. Natural and modified isoflavones. Rostov-na-Donu: Izd RGU, 1985:181

Labinskaya AS. Microbiology with the technique of microbiological research. M.: Meditsina, 1978. 392 p.

Utevskiy NL. Microbiology with the technique of microbiological tests. M.: Meditsina, 1975; 472 p.

Miller JH. Experiments in molecular genetics, Cold Spring Harbor Laboratory, 1972; 466 p.

Pirt CJ. Principles of microbe and cell cultivation. John Wiley & Sons 1975; 274 p.

Strachunekiy LS, Kozlov AYa. Antibiotics: Clinical Pharmacology: A Guide for Physicians. Smolensk Ami Pres, 1994; 207 p.

Franklin TJ, Snow GA. Biochemistry of antimicrobial action, third edition 1981

Kulaga VV, Romanenko IM, Chernomordak AV. Candida and their treatment. Kiev: Zdorov'e, 1985; 125 p.

Maksyutina NP, Komissarenko IB, Prokopenko AP et al. Herbal Remedies. Kiev: Zdorov'e, 1985. 280 p.

biopolym.cell-1998-14-6-cover.png

Downloads

Published

1998-11-20

Issue

Vol. 14 No. 6 (1998)

Section

Methods