Biopolym. Cell. 1998; 14(6):534-539.
http://dx.doi.org/10.7124/bc.0004F6
Structure and Function of Biopolymers
Modulatory effect of aluminium and its complex with quercetin on muscle contractile regulatory mechanisms
1Davidovskaya T. L., 1Bogutska K. I., 1Minchenko P. G., 1Miroshnichenko N. S.
  1. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01033

Abstract

It was shown that the guercetin decreases permeability of plasma membrane of smooth muscle of large intestine from guinea pig for calcium ions and does not influence on intracellular depots of that cations. Aluminium increases the amplitude of kalium-induced contractions, while the amplitude of caffeine-induced replies stays without changes. Aluminium complex with guercetin can penetrate to myocytcs due to solubility in lipid phase of plasma membrane and changes Ca release from sarcoplasmic reticulum. It has been found that aluminium can influence on the structural changes of actomyosin complex of skeletal muscle.
Full text: (PDF, in Russian)

References

[1] Alfrey AC, LeGendre GR, Kaehny WD. The dialysis encephalopathy syndrome. Possible aluminum intoxication. N Engl J Med. 1976;294(4):184-8.
[2] Zatta P, Favarato M, Nicolini M. Deposition of aluminum in brain tissues of rats exposed to inhalation of aluminum acetylacetonate. Neuroreport. 1993;4(9):1119-22.
[3] Babenko GA. Microelements in experimental and clinical medicine. Kiev: Meditsina, 1985. 125 p.
[4] Aggett PJ. Physiology and metabolism of essential trace elements: an outline. Clin Endocrinol Metab. 1985;14(3):513-43.
[5] Kharkevitch DA. Pharmacology. M.: Meditsina, 1993. 543 p.
[6] Mueller P, Rudin DO, Tien HT, Wescott WC. Reconstitution of cell membrane structure in vitro and its transformation into an excitable system. Nature. 1962;194:979-80.
[7] B?r?ny M, B?r?ny K, Gaetjens E, Bailin G. Chicken gizzard myosin. Arch Biochem Biophys. 1966;113(1):205-22.
[8] Fiske CH, Subbarow YJ. The colorimetric determination of phosphorus. J Biol Chem. 1925 66: 375-400.
[9] Shuba MF. The transport mechanisms by which contraction activating extra-cellular Ca2+ ions enter smooth muscle cell. 28-th Int. Cong Physiol Sci. Budapest, 1976: 88-93.
[10] Alibekov MI. [The effect of lead on the Ca2+, Mg2+-ATPase and Na+, K+-ATPase activities of the plasma membrane of smooth-muscle cells]. Fiziol Zh Im I M Sechenova. 1995;81(1):126-8.
[11] Taran TT, Kosterin SA. [The effect of Ca2+ and Mg2+ on the superprecipitation reaction and activity of actomyosin ATPase in the myometrium]. Vopr Med Khim. 1993;39(6):26-8.
[12] Zima VL, Minchenko PG. [Effect of divalent cations on superprecipitation of actomyosin from skeletal muscles]. Fiziol Zh. 1988;34(1):28-33.