Biopolym. Cell. 1993; 9(6):5-12.
Reviews
Extracellular nucleic acids as possible messengers of immune system morphogenetic function. Hypothesis about the exchange of regulatory molecules among the organism cells
1Grishok A. A.
  1. R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine
    45, Vasilkivska Str., Kyiv, Ukraine, 01022

Abstract

The problem of nucleic acids extrusion/uptake by living cells and their contents in plasma are discussed. Some regulatory RNA (DNA) are supposed to be the messengers of immune system morphogenetic function and to regulate gene expresion on posttranscriptional level. The complimentary interaction in regulating systems are considered to be important.

References

[1] Dontsov VI. Application of the theory to analyze processes hypercycle intercellular regulation tissue proliferation. Prove the existence of a specialized cell regulation system tissue proliferation. Usp Sovrem Biol. 1986; 101(1):18-29.
[2] Babayeva AG, Zotikov EA. Immunology adaptive processes of growth, proliferation, and their disorders. M.: Nauka, 1987. 207 p.
[3] Babaeva AG. Lymphocytes as regulators of proliferation and differentiation of cells of non-lymphoid organs. Vestn Akad Med Nauk SSSR. 1990;(2):43-5.
[4] Kraskina NA, Veger EM, Gutorova NM, Bliakher MS, Babaeva NV. Controlling effect of T lymphocyte suppressors on the proliferation of cells in various tissues. Biull Eksp Biol Med. 1988;105(4):464-6.
[5] Shmakov AN, Trufakin VA. The effect of T-lymphocytes on epithelial proliferation of the jejunal mucosa in thymectomized mice. Tsitologiia. 1989;31(9):1074-9.
[6] Trufakin VA, Shmakov AN. The immune system and its regulatory role in the processes of proliferation and differentiation in the body. Vestn Akad Med Nauk SSSR. 1991;(12):23-9.
[7] Glushkov AN. Immunoregulation intercellular interactions. Immunologiya. 1989;(4): 10-3.
[8] Adams DH. The problem of cytoplasmic DNA: its extrusion/uptake by cultured cells and its possible role in cell-cell information transfer. Int J Biochem. 1985;17(11):1133-41.
[9] Fedorov NA, Ianeva IS. DNA excretion by human lymphocytes. Usp Sovrem Biol. 1982;93(2):171-82.
[10] Loke SL, Stein CA, Zhang XH, Mori K, Nakanishi M, Subasinghe C, Cohen JS, Neckers LM. Characterization of oligonucleotide transport into living cells. Proc Natl Acad Sci U S A. 1989;86(10):3474-8.
[11] Yakubov LA, Deeva EA, Zarytova VF, Ivanova EM, Ryte AS, Yurchenko LV, Vlassov VV. Mechanism of oligonucleotide uptake by cells: involvement of specific receptors? Proc Natl Acad Sci U S A. 1989;86(17):6454-8.
[12] Iakubov LA, Karamyshev VN, Vlasov VV, Savenkova IV, Shcherbakov DIu. Oligonucleotide-binding proteins of Drosophila: tissue specificity. Mol Biol (Mosk). 1991;25(6):1611-4.
[13] Akhtar S, Shoji Y, Juliano R. Antisense metilphosphonate oligodeoxynucleotides enter living cells by endocytosis. J Pharm Pharmacol. 1991; (43, Suppl): 86.
[14] Zebda N, Bailly M, Brown S. et al. Corellation entre l'expression des recepteurs membranes reconnus par la RNA et Ie potentiel metastatique des melanocytes malins humains: lie Forum cancerol. (Paris, 10-11 juin, 1991). Bull. Cancer. 1991. 78, N 6: 577.
[15] Anker P, Stroun M, Maurice PA. Spontaneous extracellular synthesis of DNA released by human blood lymphocytes. Cancer Res. 1976;36(8):2832-9.
[16] Stroun M, Anker P, Beljanski M, Henri J, Lederrey C, Ojha M, Maurice PA. Presence of RNA in the nucleoprotein complex spontaneously released by human lymphocytes and frog auricles in culture. Cancer Res. 1978;38(10):3546-54.
[17] Anker P, Jachertz D, Stroun M, Brögger R, Lederrey C, Henri J, Maurice PA. The role of extracellular DNA in the transfer of information from T to B human lymphocytes in the course of an immune response. J Immunogenet. 1980;7(6):475-81.
[18] Leon SA, Shapiro B, Servi P, Parsons RG. A comparison of DNA and DNA-binding protein levels in malignant disease. Eur J Cancer. 1981;17(5):533-8.
[19] Kozak VV, NegreÄ­ GZ, Shliakhovenko VA, MikhaÄ­lenko VM, Kireeva SS. Comparative characteristics of DNA and DNA-associated plasma proteins in the normal state and in leukemia. Gematol Transfuziol. 1987;32(11):31-4.
[20] Kovbasyuk SA, Yudin VM, Trembt A.M, Protsik VS. Identification of nucleotide tropic activity in blood serum of cancer patients. Eksp Onkol. 1991; 13(5):28-31.
[21] Grikurova NK, Belokhvostov AS, SeÄ­ts IF. High-molecular forms of DNA in the blood serum of rats with Zaidel's hepatoma. Vopr Onkol. 1983;29(4):70-3.
[22] Agliullina DG, Lapina LA, Vinter VG. Changes in the RNA content of the blood plasma in rats with Ehrlich ascitic cancer. Eksp Onkol. 1988;10(4):49-51, 62.
[23] Katzmann J, Giacomoni D, Yakulis V, Heller P. Characterization of two plasmacytoma fractions and their RNA capable of changing lymphocyte surface immunoglobulins (cell conversion). Cell Immunol. 1975;18(1):98-109.
[24] Chen Y, Bhoopalam N, Yakulis V, Heller P. Changes in lymphocyte surface immunoglobulins in myeloma and the effect of an RNA-containing plasma factor. Ann Intern Med. 1975;83(5):625-31.
[25] Blinov MN, Luganova IS. Ribonucleic acids as modulators of the immune response. Mol. cellular mechanisms. homeostasis. Novosibirsk, 1987: 182-195.
[26] Ishiko O, Deguchi M, Tatsuta I, Naka K, Hirai K, Nakata S, Honda K, Sugawa T. Removal of immunosuppressive substance in cancer patients' serum. Jpn J Cancer Res. 1990;81(6-7):564-6.
[27] Kozak VV, Shliakhovenko VA, Iukhimenko MD. Adsorption on charcoal sorbents of the nucleic acids from the blood plasma of leukemia patients and from the ascitic fluid of mice with lymphoma NK/Ly. Eksp Onkol. 1986;8(2):54-7.
[28] Belokhvostov AS, Zelenkova NK, KalinovskiÄ­ VP, Mikhalevskaia LA, Perevozchikov AP. Study of the factor of ascites fluid of Erlich tumor. Vopr Onkol. 1976;22(10):66-72.
[29] Belokhvostov AS, Tomilin NV. The origin of 5 S DNA from tumor ascitic fluid. Eksp Onkol. 1984;6(4):30-3.
[30] Agliullina DG, Vegner EO, Lapina LA, Vinter VG. Characteristics of nucleic acid secreted by Ehrlich ascites carcinoma cells. Eksp Onkol. 1984;6(2):29-32.
[31] Kozak VV, Shliakhovenko VA, Iukhimenko MD. Characteristics of the nucleic component of a nucleoprotein complex secreted by tumor cells. Eksp Onkol. 1985;7(4):36-9.
[32] Vinter VG, Agliullina DG, Andreeva IN. Specificity of the action of the RNA released by Ehrlich carcinoma cells on the transplantability and growth of a homologous tumor. Vopr Onkol. 1978;24(10):38-41.
[33] Popova TI, Agliullina DG, Vinter VG. Immunomodulatory effect of low molecular weight RNA released Ehrlich ascites tumor cells. Eksp Onkol. 1991; 13(3): 44-7.
[34] Vinter VG, Alimova FK, Zotkina NA. Detection of double-stranded RNA in ascites hepatoma Zaidel. Eksp Onkol. 1982; 4(1):28-32.
[35] Folkman J. Proceedings: Tumor angiogenesis factor. Cancer Res. 1974;34(8):2109-13.
[36] Wieczorek AJ, Sitaramam V, Machleidt W, Rhyner K, Perruchoud AP, Block LH. Diagnostic and prognostic value of RNA-proteolipid in sera of patients with malignant disorders following therapy: first clinical evaluation of a novel tumor marker. Cancer Res. 1987;47(23):6407-12.
[37] Bazanova NV, SeÄ­ts IF. Can the presence of an RNA-lipoprotein complex in human blood serum give evidence of a cancerous disease?. Eksp Onkol. 1989;11(2):37-9.
[38] Vlasov VV, Godovikov AA, Zarytova VF, Ivanova EM, Nomokonova NIu. Inhibition of translation of immunoglobulin mRNA in vitro using an alkylating oligonucleotide derivative. Mol Biol (Mosk). 1990;24(1):173-8.
[39] McManaway ME, Neckers LM, Loke SL, al-Nasser AA, Redner RL, Shiramizu BT, Goldschmidts WL, Huber BE, Bhatia K, Magrath IT. Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide. Lancet. 1990;335(8693):808-11.
[40] Vlasov VV, Gorn VV, Nomokonova NIu, Fokina TN, Iurchenko LV. Suppression of translation in vitro of the mRNA of the M1 protein of influenza virus using antisense oligonucleotides. Mol Biol (Mosk). 1991;25(5):1332-7.
[41] Bevilacqua A, Erickson RP, Hieber V. Antisense RNA inhibits endogenous gene expression in mouse preimplantation embryos: lack of double-stranded RNA "melting" activity. Proc Natl Acad Sci U S A. 1988;85(3):831-5.
[42] Prasolov VS, Chumakov PM. Antisense RNA p53 inhibits proliferation of normal and transformed cells. Mol Biol (Mosk). 1988;22(5):1371-80.
[43] Tidd DM. Synthetic oligonucleotides as therapeutic agents. Br J Cancer. 1991;63(1):6-8.
[44] Soderoom T, Wagner E. G. H. A search for naturally occuring antisense RNA control systems: 20th Annu Meet Keystone Symp Mol Cell Biol. (Febr. 2-March 1, 1991). J Cell Biochem. 1991; (15D, Suppl):15.
[45] Sitikov AS, Munishkin AV. Specific suppressor T-cells secrete RNA. Dokl Akad Nauk SSSR. 1991;318(6):1486-8.
[46] Smirnov AV. Specific effects and possible mechanisms of action of exogenous RNA. Usp Sovrem Biol. 1988. 106(1 (4)):20-36.
[47] Haines DS, Strauss KI, Gillespie DH. Cellular response to double-stranded RNA. J Cell Biochem. 1991;46(1):9-20.
[48] Zemskoye VM, Zemskoye AM. Low molecular weight RNA promising immunomodulator. Immunomodulators. M., 1987: 55-66.
[49] Archer SJ. Induction of a T-cell specific antigen on bone marrow lymphocytes with thymus RNA. Immunology. 1978;34(1):123-9.
[50] Körner AM. The absence in human serum of a ribonuclease that hydrolyses double stranded RNA. Biochem Biophys Res Commun. 1976;68(3):699-703.
[51] Davidson EH, Britten RJ. Regulation of gene expression: possible role of repetitive sequences. Science. 1979;204(4397):1052-9.
[52] Dickson E, Robertson HD. Potential regulatory roles for RNA in cellular development. Cancer Res. 1976;36(9 PT 2):3387-93.
[53] Konstantinova IM, Petukhova OA, Kulichkova VA. Analysis of small antisense RNA and RNP in human cell lines. 2nd Proc. conf. "The Human Genome 91" (Pereslavl'-Zalesskiy, okt. 1991). M., 1991: 66-67.
[54] Yamagishi H, Kunisada T, Iwakura Y, Nishimune Y, Ogiso Y, Matsushiro A. Emergence of the extrachromosomal Circular DNA complexes as one of the earliest signals of cellular differentiation in the early development of mouse embryo. (mouse embryo/teratocarcinoma/mica-press-adsorption/circular DNA complex/DNA rearrangement). Dev Growth Differ. 1983;25(6):563–9.
[55] Sal'nokov KV. Extrachromosomal DNA in mammalian cells. Tsitologiia. 1990;32(11):1061-71.
[56] Abken H, Bützler C, Willecke K. Immortalization of human lymphocytes by transfection with DNA from mouse L929 cytoplasts. Proc Natl Acad Sci U S A. 1988;85(2):468-72.
[57] Clemens MJ. A potential role for RNA transcribed from B2 repeats in the regulation of mRNA stability. Cell. 1987;49(2):157-8.
[58] Ryskov AP. Double-helical structure and complementary sequence in nuclear mRNA precursors. Usp Sovrem Biol. 1978;86(2):163-76.
[59] Vlasov VV, Iurchenko LV. Mechanism for suppression mRNA translation with antisense oligonucleotides. Mol Biol (Mosk). 1990;24(5):1157-61.