An expression of specific RNA in cell cultures with an integrated asRNA genome and their possible correlation with the repression of the BLV reproduction

Tomsons, V. P.; Chernobayeva, L. G.; Kozireva, S. I.; Konicheva, V. V.; Peregoudova, Y. Y.; Murovska, M. F.; Tikhomirova, L. P.

doi:10.7124/bc.000367

Biopolym. Cell. 1993; 9(4):59-62.

http://dx.doi.org/10.7124/bc.000367

Structure and Function of Biopolymers

An expression of specific RNA in cell cultures with an integrated asRNA genome and their possible correlation with the repression of the BLV reproduction

1Tomsons V. P., 1Chernobayeva L. G., 1Kozireva S. I., 1Konicheva V. V., 1Peregoudova Y. Y., 1Murovska M. F., 1Tikhomirova L. P.

Augusts Kirhensteins Institute of Microbiology and Virology of Riga Stradins University
5 Ratsupites Str., Riga, Latvia, LV-1069

Abstract

An expression was shown of as-sequences to BLV LTR (region 341–616 n. p.) and to BLV gene X (region 6997–7929 n. p.) in FLK cell culture clones, persistently producing BLV. The detected expression of as-sequences was Found to correspond to the decrease of the RNA-dependent DNA-polymerase activity, to the concentration of the major BLV protein p24 and the production of virions.

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