Biopolym. Cell. 1993; 9(3):52-54.
Short Communications
DNA rearrangements in regenerating liver revealed by genomic fingerprinting
1Prima V. I., 1Martynenko E. I., 1Pater L. V., 1Vagin Yu. V.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


By means of genomic fingerprinting in the cells of regenerating 23 h rat liver were revealed alterations of DNA fingerprint (in the region 1,5–9 kb) comparatively to cells of the same liver at rest. It may be explained by selective under-replication of chromosomes of deviding hepatocytes.


[1] Jeffreys AJ, Wilson V, Thein SL. Hypervariable 'minisatellite' regions in human DNA. Nature. 1985 Mar 7-13;314(6006):67-73.
[2] Ivanov PL. DNA fingerprinting: hypervariable loci and genetic marking. Mol Biol (Mosk). 1989;23(2):341-7.
[3] Genome Analysis: A Practical Approach. Ed. Davies KE. Oxford University Press. 1988. 208 p.
[4] Higgins GM, Anderson RM. Experimental pathology of the liver. Arch Pathol. 1931; 12(2):186-202.
[5] DNA Cloning: a practical approach. Ed. Glover DM. Vol. III. Oxford University Press. 1987; 272 p
[6] Olszewska E, Jones K. Vacuum blotting enhances nucleic acid transfer. Trends Genet. 1988;4(4):92-4.
[7] Rogayev EI, Lenskiy AB. Probe DNA containing the gene elements of surface glycoprotein of HIV-1. effective molecular marker for human fingerprinting. Bull Exp Biol Med. 1990. 12: 646-647.
[8] Hodgson CP, Fisk RZ. Hybridization probe size control: optimized 'oligolabelling'. Nucleic Acids Res. 1987;15(15):6295.
[9] Grisham JW. A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3. Cancer Res. 1962;22:842-9.