Biopolym. Cell. 1993; 9(1):54-58.
http://dx.doi.org/10.7124/bc.00034F
Short Communications
Use of high-dispersed silice for obtaining of biologically active drug mixtures
1Galagan N. P., 2Raspopina V. A., 1Prokopenko V. V., 1Bogomaz V. I.
  1. Institute of Surface Chemistry, NAS of Ukraine
    17, Generala Naumova Str., Kyiv, Ukraine, 03164
  2. Sumyles
    12-a, Zasumskaya Str., Sumy, Ukraine, 40030

Abstract

The adsorbtion abilities of disperse silica with hydroxygroups on surface on to proteins of native mixtures of biomolecules (non-purified preparates of microbiological, animal and plant origin) in the presence of carbohydrates (polysaccharide, glycoproteins, monosaccharides). The difference having place in this process depending on participation of one or another carbohydrate are obtained. The possibility of intermolecular interaction between the proteins and polysaccharides, was observed having been in one and the same preparation and silica's ability to change them. It was shown that in biologically active mixtures of plant origin the monosaccharides can sorbe upon the SiO2 in presence of proteins, which is impossible in model experiments. The mechanism process is discussed. The data obtained may be used in purifying the biopolymers by inorganic sorbents.
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