Biopolym. Cell. 1992; 8(2):3-36.
Discussions
The problem of survival: from transitory stay in extreme situation to constant inhabiting in extreme conditions
1Kordyum V. A.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

At last decades in Ukraine (and some other regions) particular situation has taken place that mankind had never encountered before in such proportions. For this situation the transition is characteristic from episodic stay of large groups of people in extreme parameters to constant inhabiting in extreme conditions. Such inhabiting can be called the extreme life (to be more precise – constant life in lasting extreme conditions). The extreme life is provoked by proper ecological conditions and mode of people's life. But most important events (those that determine the biological peculiarities of extreme life continuance and consiquences) are realized as certain molecular events in organism. These events are defined by system of protection from external and internal damaging factors and systems of recovery for those damages that for certain reasons could not been prevented. The analysis of molecular events in organism in the course of extreme life shows that in such situation the processes of progressive ageing take place. Such processes can also accelerate themselves with growing speeds. All current phenomenology can be explained from the standpoint of extreme life and progressive-ageing of population. Using such analysis one can also prognosticate the growing sickliness of population and the deterioration in demographic situation.

References

[1] Yunisov V. Country in knockdown when 10 million children are deprived of its future Komsomolska pravda. 1991; 51, March 5.
[2] Doguzhiev V. What has been done and what lies ahead. Pravda. 1991;100, April, 26.
[3] Ostapenko V. We live in the midst of a nuclear explosion. Komsomol znamya.1991. April-May.
[4] Yablokov AV. Speech at the Congress of People's Deputies of the USSR. Izvestiya. 1989;161, June, 10: 5.
[5] Gavrylenko M. M. Pantry of sovereignty. Vechirniy Kyiv.1991; 88, May, 12.
[6] Antipenko EN, Kogut NN. Genetic effects of environmental pollution and the prospects for their prevention. Kyiv: Znanie. 1990, 89 p.
[7] "Euro X" -91. North is useful for me. Komsomol. znamya. 1991;90-91, May 17.
[8] Shkyryak-Nyzhnyk Z. For whom revive Ukraine? Vechirniy Kyiv. 1991, January, 11.
[9] Symkovych V. What does statistics know. Vechirniy Kyiv. 1991; 111, June 12.
[10] Golota VYa. To bear or not to bear. Vechirniy Kyiv.1991;178, September,17.
[11] Kravets S, Sheverev V, Glinka PA, Yskyv OP. Medical-genetic analysis of the Zhytomyr region population morbidity. Proceedings of the 2nd all-Union Congress of medical geneticists (Alma-Ata, December,4-6, 1990). 1990:217-8.
[12] Kordium VA. Gene therapy is inevitable but will we manage? Biopolym Cell. 1991; 7(2):25-72.
[13] Time for action. Pravda. 1990;339, December,5.
[14] Nagornyi AV, Nikitin VN, Bulankin IN. Problem of aging and longevity. 1963: Medgiz; 575 pages.
[15] Saprin AN. Detoxification of xenobiotics in an organism. Itogi nauki i tekhniki. Moscow, VINITI (series General probl Phys-chem Biol). 1990;22:31-122.
[16] White A, Handler F,. Smith E. Fundamentals of Biochemistry. Moscow, Mir. 1981(2):490 p.
[17] White A, Handler F,. Smith E. Fundamentals of Biochemistry. Moscow, Mir. 1981(1):534 p.
[18] Abramova ZhI, Oksengendler G.I Human and antioxidant substances. Leningrad: Nauka, 1985:230 p.
[19] Vilenchik MM. Biological basis of aging and longevity. 1987. Moscow, Znanie
[20] Alekseeva TA, Vladimirova IG, Zotin AI. The lifespan and Rubner constant at different temperatures in Drosophila melanogaster. Izv Akad Nauk SSSR Biol. 1990;(3):450-4.
[21] Ames BA. Endogenous DNA damage, aging and cancer. Age. 1989:12(3):111.
[22] Mishin VP, Bochnarev VV, Gyuryukhanov VV. Oxygen. Great Soviet encyclopedia 1979:(10); 325-326.
[23] Hurman D. The aging process. Oxygen radicals in biol. and med. : Proc. 4th, Int. congr. (la Jolla, Calif., June 27-July 3, 1987). New York; London, 1988: 1057-1065.
[24] Halliwell B. Oxidants and the central nervous system: some fundamental questions. Is oxidant damage relevant to Parkinson's disease, Alzheimer's disease, traumatic injury or stroke? Acta Neurol Scand Suppl. 1989;126:23-33.
[25] Tomilin NV. The genetic stability of the cells. Leningrad: Nauka, 1983. 156 p.
[26] Rao KS. DNA-repair in developing and aging brain. Proc Indian Nat Sci Acad. B 1990; 56(1): 141-50.
[27] Dean P. Decay processes in the cell. M. : Mir, 1981. 120 p.
[28] Makrides SC. Protein synthesis and degradation during aging and senescence. Biol Rev Camb Philos Soc. 1983;58(3):343-422.
[29] Kaler LW, Gliessman P, Craven J, Hill J, Critchlow V. Loss of enhanced nocturnal growth hormone secretion in aging rhesus males. Endocrinology. 1986;119(3):1281-4.
[30] Frolkis V. Aging and Disease. Manual on Geriatrics. M.: Meditsine, 1982:12-24.
[31] Strehler B. Time, cells and aging. –Moscow, Mir,1964. 251.
[32] Comfort A. The Biology of aging. Moscow, Mir 1967. 307 p.
[33] Vilenchik M. M. Molecular mechanisms of aging. Moscow: Nauka, 1970; 168 p.
[34] Lamb M. Biology of aging. Moscow, Mir, 1980. 206 p.
[35] Kaungo M. Biochemistry of aging. Moscow, Mir 1982. 296 p.
[36] Michelson VM, Pleskach HM., Prokofieva VV et al. Proliferation of cultured human cells in hereditary premature aging. 1st all-Union . conf. "Human Genome" (Pereslavl-Zalesskiy, 8-12 October., 1990) Proc. Sect. and poster reports. M., 1990: 173-4.
[37] Frolkis VV. Aging. Neurohumoral mechanisms. Kiev: Naukova Dumka, 1981; 320 p.
[38] Sonin MYa Economic problems arising from the population aging. Proc.. of 9th Int. Cong.. Gerontologists (Kyiv, July 2-7, 1972): 1972. V. 2:279-282.
[39] Stadtman ER, Oliver CN, Starke-Redd P. Role of oxygen radical-mediated oxidation of enzymes in aging. Age. 1989. 12(3): 111.
[40] Monnier VM. Nonenzymatic glycosylation, the Maillard reaction and the aging process. J Gerontol. 1990;45(4):B105-11.
[41] Harding JJ, Beswick HT, Ajiboye R, Huby R, Blakytny R, Rixon KC. Non-enzymic post-translational modification of proteins in aging. A review. Mech Ageing Dev. 1989;50(1):7-16.
[42] Fundolanu-Dayan D, Abrahami I, Bucher A, Gorsky M. Lipofuscins in human perioral muscles. Arch biol. 1985; 96(3):350.
[43] Pocker Y, Dahlen DD, Gulick GG, Mason K. The abnormal aging of the brain: inhibition of brain proteins by aluminium ions and its reversal by tetrahydroaminoascridnine. Age. 1989; 12(3): 121.
[44] Besterman JM, Elwell LP, Blanchard SG, Cory M. Amiloride intercalates into DNA and inhibits DNA topoisomerase II. J Biol Chem. 1987;262(27):13352-8.
[45] Slagboom PE. The aging genome: determinant or target? Report of the EURAGE meeting on 'Genomic Instability and Aging', Nerja (Spain). Mutat Res. 1990;237(3-4):183-7.
[46] Fucić A, Horvat D, Dimitrović B. Mutagenicity of vinyl chloride in man: comparison of chromosome aberrations with micronucleus and sister-chromatid exchange frequencies. Mutat Res. 1990;242(4):265-70.
[47] Gildieva BS Kazarova VL. Molecular DNA damages in norm and in various pathological processes. Experimental . mutagenesis and clinical genetics. Tashkent, 1990: 81-88.
[48] Tang XM, Chen XQ, Zhang JX, Qin WQ. Cytogenetic investigation in lymphocytes of people living in cadmium-polluted areas. Mutat Res. 1990;241(3):243-9.
[49] Písa J, Cibulka J, Ptácek M. Effect of subcutaneous application of a single cadmium dose on oocyte maturation in vitro. Physiol Bohemoslov. 1990;39(2):185-90.
[50] Cohen MD, Miller CA, Xu LS, Snow ET, Costa M. A blotting method for monitoring the formation of chemically induced DNA-protein complexes. Anal Biochem. 1990;186(1):1-7.
[51] Croom DK, Andrews PW, Nascimbeni B, Tice RR. Evaluation of chemically-induced DNA damage in germ cells of male mice using the single cell gel (SCG) electrophoretic assay. Environ Mol. Mutagenes. 1991; 17 (Suppl., 19):19.
[52] Ankina MA, Zavitaeva TA Mikhailova GF, Kozlov VM. Comparative study of the dose dependences of chromosome aberrations induced by radiation received by their micronucleus and metaphase analysis methods. Actual. probl.of rad.. biology and rad. genetics: Proceedings of the 4th All-Union. conf. devoted to the 90th anniversary of Timofeev-Ressovsky (Obninsk, 18-19 September., 1990). 1990:9-12.
[53] Timchenko OI Antipenko EN. Basics of approach to assessing mutagenic hazard of low-energy physical factors action. Proc. of 2nd all-Union congress of med. geneticists (Alma-Ata, 4-6 December., 1990) M., 1990:435-6.
[54] Randerath K, Li DH, Randerath E. Age-related DNA modifications (I-compounds): modulation by physiological and pathological processes. Mutat Res. 1990;238(3):245-53.
[55] Bodell WJ. Molecular dosimetry for sister-chromatid exchange induction and cytotoxicity by monofunctional and bifunctional alkylating agents. Mutat Res. 1990;233(1-2):203-10.
[56] Sirtori C. Senility and molecular suicide. Pharmacol Res Commun. 1984;16(10):1049-55.
[57] Shock HV. Gerontology - Past, Present and Future. Proc. of the 9th Int. Congress Gerontologists (Kyiv, July 2-7, 1972). Kiev, 1972:7-13.
[58] Bárta I, Petr T, Turek B. Delayed biological effects of low single doses of aflatoxin B1 in vivo. Sci Total Environ 1991;101(1-2):179.
[59] Watkin DM. The physiology of aging. Am J Clin Nutr. 1982; 36(4, Suppl):750-8.
[60] Wagener DK, Buffler PA. Geographic distribution of deaths due to sentinel health event (occupational) causes. Am J Ind Med. 1989;16(4):355-72.
[61] Schwartz FW. Lebenserwartung-Morbiditat-Mortalitat. Demographische Entwicklungstrends und Konsequenzen fur die arztlichen Aufgaben. Munch, med. Wochenschr. 1986; 128(5).:68-72.
[62] Harasawa M. Special features of the diseases in the elderly. Asian Med J. 1990; 33(2):61-6.
[63] Kohn RR. Aging and age-related diseases: normal processes. Relat. between norm, aging and diseases symp., Amer. aging assoc. (New York, sept., 1982). New York, 1985: 1-44.
[64] Granata Q. Geriatra. Med. geriatr. 1988; 20(5):338-42.
[65] Walford RL. Studies in immunogerontology. J Am Geriatr Soc. 1982;30(10):617-25.
[66] Mazay GG, Kovalchuk VA, Shumlyanskiy LA. Evaluation of biological age of metallurgical plant. workers. Proc. Research Institute of Occupational Health and prof. diseases of the USSR AMS. 1990; 2(42):282-3.
[67] Mrcarica E, Zivanov-Curlis I. Promene u duzini zivota vinske musice Drosophila melanogaster izazvane delovanjem fenola. Acta med medianae. 1990; 29(4):5-11.
[68] Raloff Y. Mom's fatty diet may induce child's cancer. Sci News. 1990; 137(1):5.
[69] Child leukemia may be linked to fathers radiation doses. Nucl. News (USA). 1990; 33(3): 19-20.
[70] Korkushko OV, Mints AYa Premature aging, risk factors. Ways of preventing . Manual on Geriatrics. M.: Medicine, 1982: 25-34.
[71] Srám RJ, Binková B, Topinka J, Fojtíková I. Inhibition of DNA repair synthesis in the rat by in vivo exposure to psychotropic drugs and reversal of the effect by co-administration with alpha-tocopherol. Mutat Res. 1990;244(4):331-5.
[72] Manna GK, Roy U. Genotoxic potential of the antibacterial drug, norbactin tested in mice. Cytologia. 1990;55(4):581–8.
[73] Bali D, Singh JR, Singh H, Sandhu D. In vitro and in vivo genotoxicity evaluation of hormonal drugs. I. Hydrocortisone. Environ Mol Mutagen. 1990;16(4):250-4.
[74] Slamenová D, Bohusová T, Oravec C. Inhibitory effect of theophylline on repair of potentially lethal MMS-induced damages to DNA in V79 cells. Mutat Res. 1990;242(2):127-34.
[75] Khesin RB. Genome instability. Moscow, Nauka, 1984; 472 p.