Biopolym. Cell. 1991; 7(6):102-106.
Short Communications
The 2'5'-oligoadenylat synthetase activity increase in interferon treated malignant kidney and bladder cells
1Verkhatskaya A. A., 1Prokhnevskaya O. L., 1Zavelevich M. P., 1Matsuka G. Kh.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

The article deals with the investigation aimed to use the 2'5'oligoadenylate synthetase activity as the marker of interferon-sensitivity of some cells.

References

[1] Strander H. Interferon treatment of human neoplasia. Adv Cancer Res. 1986;46:1-265.
[2] Balkwill FR, Griffin DB, Lee AE. Interferons alpha and gamma differ in their ability to cause tumour stasis and regression in vivo. Eur J Cancer Clin Oncol. 1989;25(10):1481-6.
[3] Farrell PJ, Sen GC, Dubois MF, Ratner L, Slattery E, Lengyel P. Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA. Proc Natl Acad Sci U S A. 1978;75(12):5893-7.
[4] Kortsaris A. 2', 5' oligo (A) synthetase levels in interferon-sensitive or resistant breast cancer cells. Microbiologica. 1988;11(2):111-7.
[5] Chao TY, Chu TM. Effect of indomethacin on tumor-infiltrating lymphocytes of a spontaneously developed murine mammary adenocarcinoma. Cancer Immunol Immunother. 1989;30(3):158-64.
[6] Minks MA, Benvin S, Maroney PA, Baglioni C. Synthesis of 2'5'-oligo(A) in extracts of interferon-treated HeLa cells. J Biol Chem. 1979;254(12):5058-64.
[7] Hovanessian AG, Laurent AG, Chebath J, Galabru J, Robert N, Svab J. Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies. EMBO J. 1987;6(5):1273-80.
[8] Barouki FM, Witter FR, Griffin DE, Nadler PI, Woods A, Wood DL, Lietman PS. Time course of interferon levels, antiviral state, 2',5'-oligoadenylate synthetase and side effects in healthy men. J Interferon Res. 1987;7(1):29-39.
[9] Ostlund L, Einhorn S, Robèrt KH. Induction of 2',5'-oligoadenylate synthetase and blast transformation in primary chronic lymphocytic leukemia cells following exposure to interferon in vitro. Cancer Res. 1986;46(4 Pt 2):2160-3.
[10] Ostlund L, Grandér D, Juliusson G, Robèrt KH, Lundgren E, Einhorn S. Alpha-interferon receptors in malignant B-cells from patients with chronic lymphocytic leukemia: relation to induction of 2'-5'-oligoadenylate synthetase and blast transformation. Cancer Res. 1989;49(12):3425-30.
[11] Porzsolt F, Digel W, Jacobsen H, Mittnacht S, Kirchner H, Heimpel H. Different antitumor mechanisms of interferon-alpha in the treatment of hairy cell leukemia and renal cell cancer. Cancer. 1988;61(2):288-93.