Biopolym. Cell. 1991; 7(1):5-9.
http://dx.doi.org/10.7124/bc.000047
Conceptual approach to the classification of mutations in homologous polypeptides
1Chavchanidze V. V., 1Kvinikhidze K. S.
  1. Institute of Systems Management Sciences GSPC,
    Tbilisi, USSR

Abstract

As based on a notion of concept-object a computable notion «concept-biopolymer», a hypothetical generalized biopolymer, is introduced. It may be a nuclear acid (DNA, RNA), proteins, etc. This approach makes it possible: 1) to reproduce changes, taking place in the primary structure of m-RNA in the process of evolution; 2) to classify point mutations in nucleotid matrix stipulating changes in the primary protein structure; 3) to supplement the family of homologous proteins, i. e. to reproduce new proteins which, evidently, have taken place in the process of evolution, or now exist in the period of morphogenesis and differentiation.
Full text: (PDF, in Russian)

References

[1] Chavchanidze VV. The theory of natural and artificial conceptual intelligence. Materials IV MOKII. Tbilisi, 1976:7-17.
[2] Chavchanidze VV. Towards the general theory of conceptual systems. Kybernetes. 1972; 3(1):17-25.
[3] Kvinikhidze KS. Using a conceptual approach to identify additional amino acid sequences. Soobshcheniya GSSR. 1985; 118(1):57-60.
[4] Kvinikhidze KS, Chavchanidze VV. Conceptual approach to the description of the evolution of protein structures. Soobshcheniya GSSR. 1976; 84(2):337-40.
[5] Kvinikhidze KS, Chavchanidze VV. Application of conceptual approach to describe the evolution of protein structure. Rep. at 8-th Int. Congr. on Cybernetics. Namur, 1976:839-47.
[6] Chavchanidze VV., Kvinikhidze KS. Biological structures computer modelling. Intern. symposium. Physical Chemistry of DNA: Proc. of reports. Tbilisi, 1987:223.
[7] Carnap R. The logical foundation of probability. Chicago: Univ. Chicago press. 1950:122-126.
[8] Chavchanidze VV. On the deciphering of the DNA code (RNA) and biological compounds incorporating. Soobshcheniya GSSR. 1966; 44(1):19-26.
[9] Chavchanidze VV, Kvinikhidze KS. About creating a calculated concept of "concept-object". Theory and device of automatic control systems. Tbilisi Metsniereba, 1989:156-162.
[10] Dayhoff MO. Atlas on protein sequences and structure. New York: Silver Spring Md., 1969:D8-D96.