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Structure and Function of Biopolymers
Acidic polypeptides as inhibitors of the repair of double-strand DNA breaks
- Institute of Biological Physics, Academy of Sciences of the USSR
Pushchino, Moscow Region, USSR
The ability of polypeptides consisting of aspartic and glutamic acids to inhibit the repair of double-strand DNA breaks induced in Y-irradiated Chinese hamster and HeLa cells was shown. A complete inhibiton of the double-strand DNA breaks repair was observed under the concentrations of 20 jimoles/1 (polyglutamic acid with molecular weight 2000–15000 daltons) and 100 umoles/1 (aspartylglutamic acid with moSccuar weight 1500-4500 daltons). Both polypeptides were low toxic at the given concentrations, their inhibitory effect being reversible.
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