Biopolym. Cell. 1990; 6(6):22-31.
A computer system for the analysis of a poly-nucleotide context for the role it plays in the appearing of point mutations
- Institute of Cytology and Genetics, Siberian Branch of the Academy of Sciences of the USSR
It has become a fact by now that the polynucleotide context of specified variants of the polynucleotide sequences is of profound importance as for the appearing of mutations. However, the molecular mechanisms by means of which the polynucleotide context affects the appearance of mutations are what still hangs in the balance. The efficacious methods of sequencing led to the fast piling-up of data on the mutation localization in the sequences. We have worked out a computer system which proved to promote analysing the features of a polynucleotide context that influences the mutations appearing. At present it consists of two substructures, namely, TheMutational Events Data Bank and The Complex of Methods to Analyse The Correlation Between The Context Features And The Appearing of Singular and Multiple Substitutions.
 Ripley LS. Model for the participation of quasi-palindromic DNA sequences in frameshift mutation. Proc Natl Acad Sci U S A. 1982;79(13):4128-32.
 Kolchanov NA, Solovyov VV, Rogozin IB. Peculiarities of immunoglobulin gene structures as a basis for somatic mutation emergence. FEBS Lett. 1987;214(1):87-91.
 Burns PA, Gordon AJ, Glickman BW. Influence of neighbouring base sequence on N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis in the lacI gene of Escherichia coli. J Mol Biol. 1987;194(3):385-90.
 Golding GB, Glickman BW. Sequence-directed mutagenesis: evidence from a phylogenetic history of human alpha-interferon genes. Proc Natl Acad Sci U S A. 1985;82(24):8577-81.
 Drake JW, Baltz RH. The biochemistry of mutagenesis. Annu Rev Biochem. 1976;45:11-37.
 Salganik RI, Mazin AV, Dianov GL, Ovchinnikova LP. Induction of repetitive nucleotide sequences. The probable mechanisms of genome evolution and gene conversion. Genetika. 1984;20(8):1244-54.
 Lewin B. Genes. (2nd Edition). New York, John Wiley & Sons, 1985; 734 p.
 Watson JD. Molecular biology of the gene. New York, W. A. Benjamin, 1970; 2nd Ed. 662 p.
 Meselson MS, Radding CM. A general model for genetic recombination. Proc Natl Acad Sci U S A. 1975;72(1):358-61.
 Kunkel TA. The mutational specificity of DNA polymerases-alpha and -gamma during in vitro DNA synthesis. J Biol Chem. 1985;260(23):12866-74.
 Topal MD, Eadie JS, Conrad M. O6-methylguanine mutation and repair is nonuniform. Selection for DNA most interactive with O6-methylguanine. J Biol Chem. 1986;261(21):9879-85.
 Gearhart PJ, Bogenhagen DF. Clusters of point mutations are found exclusively around rearranged antibody variable genes. Proc Natl Acad Sci U S A. 1983;80(11):3439-43.
 Reynaud CA, Anquez V, Grimal H, Weill JC. A hyperconversion mechanism generates the chicken light chain preimmune repertoire. Cell. 1987;48(3):379-88.
 Rogozin IB, Solovyev VV, Kolchanov NA. Context predetermination of the mutation process (somatic, spontaneous and induced point mutations). Novosibirsk, (Preprint. USSR Academy of Sciences, Institute of Cytology and Genetics, N 08031). 1988, 54 p.
 Berek C, Griffiths GM, Milstein C. Molecular events during maturation of the immune response to oxazolone. Nature. 1985 Aug 1-7;316(6027):412-8.
 Rabbitts TH, Hamlyn PH, Baer R. Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma. Nature. 1983 Dec 22-1984;306(5945):760-5.
 Hauser J, Levine AS, Dixon K. Unique pattern of point mutations arising after gene transfer into mammalian cells. EMBO J. 1987;6(1):63-7.