Biopolym. Cell. 1990; 6(4):51-59.
http://dx.doi.org/10.7124/bc.00027D
Structure and Function of Biopolymers
Structural characteristics of the integration regions of NPV DNA and host cell in the Galleria mellonella genome
1Miryuta N. Yu., 1Strokovskaya L. I., 1Skuratovskaya I. N.
  1. Institute of Molecular Biology and Genetics, Academy of Sciences of the Ukrainian SSR
    Kiev, USSR

Abstract

The physical state of the viral genome in the cell and certain structural characteristics of binding sites of virus and cell sequences in Gallerla mellonella DNA and NPV DNA have been investigated. The possibility of covalent bond between genome DNAs of virus and cell is shown. The studies of kinetic and thermal fractions obtained from G. mellonella larvae of the Prague stock for DNA with different weights have permitted localizing NPV DNA regions containing homology regions, showing linkage between virus and cell DNA in the cell genome, investigating virus DNA regions adjacent to cell DNA. This DNA proved to contain homology regions and neighbouring virus DNA fragments. A model of integration of NPV genome with G. mellonella larvae genome has been suggested.
Full text: (PDF, in Russian)

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