Biopolym. Cell. 1990; 6(2):87-90.
Structure and Function of Biopolymers
Interaction of methemoglobin with phospholipid vesicles
1Gorbenko G. P., 1Dreval V. I.
  1. Kharkov State University
    Kharkov, USSR


The melhemoglobin binding to phosphatidylcholine liposomes has been investigated by the equilibrium adsorption technique. The experimental isotherm has been treated in terms of two-dimensional lattice model of protein incorporation into bilayer. It was shown that the model involved may be used to analyze the integral protein interaction with the membrane lipid matrix.


[1] Stankowski S. Large-ligand adsorption to membranes. III. Cooperativity and general ligand shapes. Biochim Biophys Acta. 1984;777(2):167-82.
[2] Stankowski S. Large-ligand adsorption to membranes. II. Disk-like ligands and shape dependence at low saturation. Biochim Biophys Acta. 1983;735(3):352–60. .
[3] Rozenberg GIa, Viazova EP, Ivanova GN, Ushakova MM, Ivanov IuG. Isolation of a purified preparation of hemoglobin and study of its properties. Probl Gematol Pereliv Krovi. 1975;20(11):25-9.
[4] Bossi L, Alem? S, Calissano P, Marra E. Interaction of different forms of haemoglobin with artificial lipid membranes. Biochim Biophys Acta. 1975;375(3):477-82.
[5] Kimelberg HK. Protein-liposome interactions and their relevance to the structure and function of cell membranes. Mol Cell Biochem. 1976;10(3):171-90.
[6] Chupin VV, Ushakova IP, Bondarenko SV, Vasilenco IA, Serebrennikova GA, Evstigneeva RP, Rosenberg GJ, Koltsova GN. 31P NMR study on methemoglobin interaction with model membranes. Russian Journal of Bioorganic Chemistry. 1982; 8(9):1275-80.
[7] Ushakova IP, Vasilenko IA, Serebrennikova GA, Evstigneeva RP. Fluorescence studies of methaemoglobin interaction with phospholipid bilayer membranes. Russian Journal of Bioorganic Chemistry. 1981; 7(4):613-20.
[8] Seleznev SA, Gromov NG. Education of hemoglobin-lipid complexes as a model of interaction of the main components of cell membranes. Biofizika. 1983; 28(3):521.