Biopolym. Cell. 1990; 6(2):71-76.
Transfer of cloned human gene ApoA1 into adult and old rabbits
1Shulhzenko V. N., 1Novikova S. N., 1Kostetsky I. E., 1Bogatskaya L. N., 1, 2Frolkis V. V., 1Kordium V. A.
  1. Institute of Molecular Biology and Genetics, Academy of Sciences of the Ukrainian SSR
    Kiev, USSR
  2. Institute of Gerontology, Academy of Medical Sciences of the Ukrainian SSR
    Kiev, USSR


Recombinant DNA containing Alu-repeat and cloned human ApoAl gene has been constructed. Genetic material included into a lyposome and injected into adult and old rabbits has resulted in the appearance of human gene ApoAl protein product in the rabbit blood. This product was identified by agarose gel immunoelectrophoresis with specific antiserum. Essential rearrangement of cholesterol content and different classes of lypoprolcins has been observed in the rabbit blood.


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