Biopolym. Cell. 1989; 5(6):83-86.
Cell Biology
Synchronous changes of c-fos RNA and B2+mRNAx concentrations during prereplicative period in regenerating rat liver
1Prima V. I., 1Clochko T. A., 1Obolenskaya M. Yu., 2Ivanov P. L., 2Ryskov A. P., 1Platonov O. M.
- Institute of Molecular Biology and Genetics, Academy of Sciences of the Ukrainian SSR
Kiev, USSR - Institute of Molecular Biology, Academy of Sciences of the USSR
Moscow, USSR
Abstract
The relative abundance of c-fos RNA and mRNA containing repetitive sequence B2 (B2+mRNAx) has been studied in nuclear and poly(A)+ cytoplasmic RNA of regenerating liver during 0–12 h after partial hepatectomy. The data of DNA-RNA hybridization reveal that c-fos transcripts are mainly localized in nucleus and their relative abundance is maximal 0.5 and 12 h after operation. On the contrary B2+mRNAx is mainly localized in poly (A) + cytoplasmic RNA and its concentration is the lowest in the same periods after operation. The differences in the investigated gene expression are possibly connected with functional peculiarities of terminal products of both genes.
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