Biopolym. Cell. 1989; 5(2):79-88.
http://dx.doi.org/10.7124/bc.0000AB
Cell Biology
Partial restriction of genome expression – a component of its work reprogramming in regenerating liver of mammals
1Obolenskaya M. Yu., 1Prima V. I., 1Gerasimova T. B., 1Platonov O. M.
  1. Institute of Molecular Biology and Genetics, Academy of Sciences of the Ukrainian SSR
    Kiev, USSR

Abstract

The synthesis and distribution of RNA in different compartments of hepatocyte were investigated during the prereplicative period in regenerating liver. On the basis of changes in the activity of some DNA sequences the authors discuss the idea of partial restriction of genome expression as a means to save reserves of a cell and to reprogramme its work during the pronounced metabolic transition.
Full text: (PDF, in Russian)

References

[1] Baserga R. Biochemistry of the cell cycle: A review. Cell proliferation. 1968. 1(1):167-191.
[2] Terskikh VV, Zosimovskaia AI, Abuladze MK. Macromolecular syntheses and cell population kinetics during induction of proliferation in stationary cultures of Chinese hamster cells. Tsitologiia. 1974;16(3):317-21. Russian.
[3] Bucher NLR., Malt RA. Regeneration of liver and kidney. Boston: Little Brown and Co., 1971. 248 p.
[4] Tsanev R. Cell Cycle and Liver Function. Results and Problems in Cell Differentiation. Springer Science. 1975;197-248.
[5] Iakovlev AIu. Hepatocyte dynamic reserve: the mechanism for the assurance of specialized functions in the regenerating liver. Tsitologiia. 1979;21(11):1243-52.
[6] Yepifanova OI, Terskikh VV, Polunovskiy VA Resting cells. Properties and functions in the organism. Moscow, Nauka, 1983; 176 p.
[7] Fausto N. Messenger RNA in regenerating liver: implications for the understanding of regulated growth. Mol Cell Biochem. 1984;59(1-2):131-47.
[8] Zelenin AV, Kushch AA. Chromatin activation and various problems of genetic activity regulation in eukaryotic cells. Mol Biol (Mosk). 1985;19(1):285-94.
[9] Greengard O, Federman M, Knox WE. Cytomorphometry of developing rat liver and its application to enzymic differentiation. J Cell Biol. 1972;52(2):261-72.
[10] Jungermann K, Katz N. Functional hepatocellular heterogeneity. Hepatology. 1982;2(3):385-95.
[11] Stocker E. Alterabhangige zellproliferationskinetik und regenerationskapazitat im Liberepithel der Ratte. Actuelle Gerontologie. 1971; 1(11):659-665.
[12] Obolenskaya MYu, Prima VI Kulikovskaya IA, Platonov OM. Nuclear RNA at the early stage of liver regeneration. Biopolym Cell. 1987; 3(1):27-35.
[13] Obolenskaia MIu, Gerasimova TB, Bilich KM, Platonov OM. Intracellular distribution of newly formed hepatocyte RNA in the 1st hours following partial hepatectomy. Tsitol Genet. 1987;21(5):376-82.
[14] Glazer RI. The action of cordycepin on nascent nuclear RNA and poly(A) synthesis in regenerating liver. Biochim Biophys Acta. 1976;418(2):160-6.
[15] Platonov OM, Gerasimova TB, Andrianov VM, Smal'ko PIa, Korniushina TV. Changes in the cytoplasmic ultrastructure and polyribosome content of rat liver cells in the 1st hours after a partial hepatectomy. Tsitol Genet. 1981;15(5):25-8.
[16] Platonov OM, Gerasimova TB, Smal'ko PIa, Zheliabovskaia SM, Korniushina TV. Peculiarities of nuclear genome transcription at early stages of liver regeneration. Possible role of mitochondrial translation in activation of nuclear RNA biosynthesis. Biokhimiia. 1981;46(11):2074-81.
[17] Zheliabovskaia SM, Sverdel VP, Lebedeva LM, Bur'ianovskii, Platonov OM. Peculiarities of nuclear genome transcription in the early stages of liver regeneration. Complex nature of the activating effect of the cytoplasmic regenerating factor on transcription in isolated rat liver nuclei. Biokhimiia. 1983;48(11):1774-7.
[18] Gerasimova TB, Obolenskaia MIu, Platonov OM. Autoradiographic study of RNA synthesis and secretion into the cytoplasm during the early stages of liver regeneration. Tsitol Genet. 1980;14(3):77-82.
[19] Iaremchuk AD, El'skaia AV. Biological activity of tRNA, aminoacyl-tRNA-synthetases and composition of their high molecular weight complexes in regenerating rat liver. Ukr Biokhim Zh. 1983;55(4):363-7.
[20] Iaremchuk AD, Tarasiavichene LE, Kondratiuk TP, El'skaia AV. Aminoacyl-tRNA-synthetases and their high molecular weight complexes in the regenerating rat liver. Mol Biol (Mosk). 1984;18(5):1336-41.
[21] Atryzek V, Fausto N. Accumulation of polyadenylated mRNA during liver regeneration. Biochemistry. 1979;18(7):1281-7.
[22] Meyerson FZ, Pomoynitskiy VD, Yampol'skiy BA. The role of mitochondrial biogenesis in the adaptation to high altitude hypoxia. Genetic functions of cytoplasm organelles. Material I All-Union symp. on cytoplasmic heredity. Leningrad, Nauka, 1974; 146-54.
[23] Mashanskiy VF, Matiyenko-Maksimova YeB, Timina ZA, et al. Phenomena of early "spike" in the structural components of the cell. Izv akad nauk Mold SSR. 1981; (4):5-16.
[24] Kovach L, Shubik Yu. Mitochondria and cell function. Questions of General Genetics: Proc. XIV Int. congr. of genetics. Moscow, Nauka, 1981; 383-9.
[25] Wunderlich F. In vitro rRNP-transport-intranuclear retention mechanisms. Nuclear envelope structure and RNA maturation . Eds E. A. Smuckler, H. A. Clawson - New York: Alan R. Liss Inc., 1985:579-584.
[26] Manteifel' VM, Bandrina IN, Zelenin AV. Electron microscopic examination of hepatocyte nuclei within first hours after partial hepatectomy. III. Changes of DNP fiber diameters of condensed chromatin. Mol Biol (Mosk). 1980;14(3):568-74.
[27] Dabeva MD, Dudov KP. Transcriptional control of ribosome production in regenerating rat liver. Biochem J. 1982;208(1):101-8.
[28] Dabeva MD, Dudov KP, Hadjiolov AA, Emanuilov I, Todorov BN. Intranuclear maturation pathways of rat liver ribosomal ribonucleic acids. Biochem J. 1976;160(3):495-503.
[29] Sverdel VP, Zhelyabovskaya SM, Lebedeva LM, Burianovsky LN, Platonov OM. The elongation factor for synthesis of RNA from hepatocytes cytosol of rats after 1 h after partial hepatectomy. Doklady Akad Nauk Ukr SSR. Ser B. 1983; (8):71-3.
[30] Baserga R, Sasaki T, Whitlock JP, Jr. The prerep licative phase of isoproterenolstimulated DNA synthesis. Biochemistry of cell division. Ed. R. Baserga. Illinois: Springfield, 1969: 77-90.
[31] Grady LJ, Campbell WP, North AB. Nonrepetitive DNA transcription in normal and regenerating rat liver. Nucleic Acids Res. 1979;7(1):259-69.
[32] Grady LJ, Campbell WP, North AB. Sequence diversity of nuclear and polysomal polyadenylated and non-polyadenylated RNA in normal and regenerating rat liver. Eur J Biochem. 1981;115(2):241-5.
[33] Prima VI, Lisitsa EG, Platonov OM. Features of nuclear genome transcription at early steps of liver regeneration: expression of DNA fractions with different repeating sequence frequencies. Biokhimiia. 1982;47(1):145-52.
[34] Colbert DA, Tedeschi MV, Atryzek V, Fausto N. Diversity of polyadenylated messenger RNA sequences in normal and 12-hr regenerating liver. Dev Biol. 1977;59(2):111-23.
[35] Krieg L, Alonso A, Volm M. Kinetic complexity of nuclear poly(A)-containing RNA in normal and regenerating rat liver. Eur J Biochem. 1979;96(1):77-85.
[36] Greene RF, Fausto N. Analysis of gene expression in regenerating rat liver by hybridization of nuclear and cytoplasmic RNA with DNA. Cancer Res. 1977;37(1):118-27.
[37] Davidson EH, Britten RJ. Regulation of gene expression: possible role of repetitive sequences. Science. 1979;204(4397):1052-9.
[38] Khandekar P, Saidapet C, Krauskopf M, Zarraga AM, Lin WL, Mendola C, Siddiqui MA. Co-ordinate control of gene expression. Muscle-specific 7 S RNA contains sequences homologous to 3'-untranslated regions of myosin genes and repetitive DNA. J Mol Biol. 1984;180(3):417-35.
[39] Powell DJ, Friedman JM, Oulette AJ, Krauter KS, Darnell JE Jr. Transcriptional and post-transcriptional control of specific messenger RNAs in adult and embryonic liver. J Mol Biol. 1984;179(1):21-35.
[40] Friedman JM, Chung EY, Darnell JE Jr. Gene expression during liver regeneration. J Mol Biol. 1984;179(1):37-53.
[41] Makino R, Hayashi K, Sugimura T. C-myc transcript is induced in rat liver at a very early stage of regeneration or by cycloheximide treatment. Nature. 1984 Aug 23-29;310(5979):697-8.
[42] Prima VI, Obolenskaya MYu, Platonov OM. Early changes in the qualitative composition of RNA in regenerating liver cells. Abstracts of IX All-Union symp. "Structure and function of the cell nucleus." Chernogolovka, 1987; 248.
[43] Kruijer W, Skelly H, Botteri F, van der Putten H, Barber JR, Verma IM, Leffert HL. Proto-oncogene expression in regenerating liver is simulated in cultures of primary adult rat hepatocytes. J Biol Chem. 1986;261(17):7929-33.
[44] Biesiada E, Wisniewski J, Krawezyk Z, Chorazy M. Expression of c-fos, c-myc and hsp70 genes at early stages of the regenerating rat liver Bull. Polish Acad Sci. 1987; 35(7-9):165-171.
[45] Denhardt DT, Edwards DR, Parfett CL. Gene expression during the mammalian cell cycle. Biochim Biophys Acta. 1986;865(2):83-125. Review.
[46] Carr BI, Huang TH, Buzin CH, Itakura K. Induction of heat shock gene expression without heat shock by hepatocarcinogens and during hepatic regeneration in rat liver. Cancer Res. 1986;46(10):5106-11.
[47] Faliks D, Meyuhas O. Coordinate regulation of ribosomal protein mRNA level in regenerating rat liver. Study with the corresponding mouse cloned cDNAs. Nucleic Acids Res. 1982;10(3):789-801.
[48] Lewin B. Genes. (2nd Edition). New York, John Wiley & Sons, 1985; 734 p.
[49] Neyfakh AA, Yermolayev SV, Klyachko OS. The problem of a change proteins in developing. Ontogenez. 1986; 17(4):434.