Biopolym. Cell. 2024; 40(3):244-244.
http://dx.doi.org/10.7124/bc.000AF2
Chronicle and Information
Natural alkaloids noncovalently bound to C60 fullerene are potent anticancer phytotherapeutic agents
1Matyshevska O. O., 1Horak I. R., 1Skaterna T. D., 1Krysiuk I. P., 2Lugovskyi S. P., 3Prylutskyy Yu. I., 1Drobot L. B.
  1. O. V. Palladin Institute of Biochemistry, NAS of Ukraine
    9, Leontovycha Str., Kyiv, Ukraine, 01054
  2. D. F. Chebotarev Institute of Gerontology, NAMS of Ukraine
    67, Vyshgorodska Str., Kyiv, Ukraine, 04114
  3. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01601

Abstract

Aim. Conventional anticancer drugs have a number of known limitations but the development of new ones takes a long time, requires significant funding, and has a low success rate. Repurposing of pharmacologically active plant alkaloids Berberine (Ber) and Piperlongumine (Pl) and finding nanoplatforms for their delivery to cancer cells seems promising to be addressed. The ability of the C60 fullerene (C60) carbon nanostructure to be functionalized with therapeutic agents makes it a potential drug carrier. The aim of this study was to prove a non-covalent functionalization of C60 with Ber or PL and to check the effectiveness of these nanocomplexes against Lewis lung carcinoma (LLC) both in vitro and in vivo. Conclusions. The proposed nanocomplexes of alkaloids with C60 represent promising drugs for the treatment of metastatic lung cancer.
Keywords: С60, alkaloids, nanocomplexes, lung carcinogenesis, tumor growth, EMT, metastasis
Full text: (PDF, in English)

References

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