Alteration in the ratio of S6K1 isoform expression modifies the response of cancer cells to the influences of the tumor microenvironment

Hotsuliak, N. Ya.; Kosach, V. R.; Filonenko, V. V.; Khoruzhenko, A. I.

doi:10.7124/bc.000AF7

Biopolym. Cell. 2024; 40(3):198-198.

http://dx.doi.org/10.7124/bc.000AF7

Chronicle and Information

Alteration in the ratio of S6K1 isoform expression modifies the response of cancer cells to the influences of the tumor microenvironment

1Hotsuliak N. Ya., 1, 2Kosach V. R., 1Filonenko V. V., 1Khoruzhenko A. I.

Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143
Enamine Ltd.
78, Winston Churchill Str., Kyiv, Ukraine, 02094

Abstract

Aim. This work aimed to clarify the impact of mTOR/S6K1 cell signaling, with an emphasis on S6K1 isoforms, in the response of tumor cells to fibroblast influence in vitro. Conclusions. The data highlight the significance of the ratio of S6K1 isoform expression in cancer cells for their response to microenvironment factors.

Keywords: S6K1 isoforms, tumor microenvironment, cell locomotion,

Full text: (PDF, in English)