Biopolym. Cell. 2024; 40(3):198-198.
http://dx.doi.org/10.7124/bc.000AF7
Chronicle and Information
Alteration in the ratio of S6K1 isoform expression modifies the response of cancer cells to the influences of the tumor microenvironment
1Hotsuliak N. Ya., 1, 2Kosach V. R., 1Filonenko V. V., 1Khoruzhenko A. I.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143
  2. Enamine Ltd.
    78, Winston Churchill Str., Kyiv, Ukraine, 02094
Aim. This work aimed to clarify the impact of mTOR/S6K1 cell signaling, with an emphasis on S6K1 isoforms, in the response of tumor cells to fibroblast influence in vitro. Conclusions. The data highlight the significance of the ratio of S6K1 isoform expression in cancer cells for their response to microenvironment factors.
Keywords: S6K1 isoforms, tumor microenvironment, cell locomotion,
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