Biopolym. Cell. 2024; 40(3):191-191.
http://dx.doi.org/10.7124/bc.000AE3
Chronicle and Information
Genetic effects of variation at ADH1B-ADH1C locus on substance use disorders and physical health traits
1Bashynska V. V., 2Zahorodnia O., 2Borysovych Yu., 2Zaplatnikov Yu., 2Vasilyeva V., 2Arefiev I., 3Krasnienkov D., 3Zabuga O., 2Darvishov N., 4Osichanskaya D., 4Karapetyan A., 5Melnychuk O., 5Boiko O., 5Zil'berblat G. M., 1Turos O. I., 6Prokopenko I. O., 6, 7Kaakinen M. A.
  1. O.M.Marzeiev Institute of Public Health, NAMS of Ukraine
    50, Hetmana Pavla Polubotka Str., Kyiv, Ukraine
  2. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01601
  3. Chebotarov Institute of Gerontology, NAMS of Ukraine
    67, Vyshgorodska Str., Kyiv, Ukraine, 04114
  4. MedLux Medical Centre
    6/8, Mykilsko-Botanichna Str., Kyiv, Ukraine, 01033
  5. Kyiv City Psychoneurological Hospital Number 3,
    7, Pavlova Str., Glevakha, Kyiv region, Ukraine, 08631
  6. University of Surrey
    Stag Hill, University Campus, Guildford, United Kingdom, GU2 7XH
  7. Imperial College London
    South Kensington Campus, London, United Kingdom, SW7 2AZ

Abstract

Aim. We investigated association of a validated in other populations GWAS-identified AD risk locus ADH1B-ADH1C rs1789891 [2-4] with a range of SUDs in Ukrainians and evaluated its potential effects on other traits in GWAS summary statistics from Biobanks. Conclusions. Variations at ADH1B-ADH1C may have pleiotropic effects on SUDs as well as some physical health traits.
Keywords: genetic association study, substance use disorders, Ukrainians, multi-phenotype study, ADH1B-ADH1C, pleiotropy
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