Aim. To evaluate morphological and biochemical changes in the liver of rats with toxic hepatitis (TH) without and after drug correction. Conclusions. It was established that the consumption of both methadoxin and metabiotics in the post–toxic period caused a decrease in hepatocyte degeneration. TG, regardless of the correction method, was characterized by an increase in the level of PUFA. Under the influence of methadoxin, the concentration of MUFA decreased more than in the group receiving metabiotics.