Biopolym. Cell. 2024; 40(3):187-187.
http://dx.doi.org/10.7124/bc.000AC0
Chronicle and Information
Valproic acid (VPA) exerts different effects on proliferation and viability of 4T1 parental and 4T1 cells overexpressing adaptor protein Ruk/CIN85 by triggering metabolic reprograming in type specific manner
1Hudkova O. O., 1Latyshko N. V., 1Kishko T. O., 1Krysiuk I. P., 1Khudiakova O. V., 1Skaterna T. D., 1Horak I. R., 1Drobot L. B.
  1. O.V. Palladin Institute of Biochemistry, NAS of Ukraine
    9, Leontovycha Str., Kyiv, Ukraine, 01054

Abstract

Aim. We previously demonstrated that mouse breast adenocarcinoma 4T1 cells overexpressing adaptor protein Ruk/CIN85 (4T1 RukUp) acquired a malignant phenotype associated with cancer stem cells features compared with parental 4T1 cells (4T1 Mock) [1]. VPA, a broad Class I histone deacetylases inhibitor, is widely used in cancer therapy [2]. The study aimed was to evaluate the effect of VPA on Warburg effect dependent on Ruk/CIN85 expression in 4T1 cells. Conclusions. The results obtained demonstrate that VPA restores the coupling between oxidative phosphorylation and glycolysis in 4T1 RukUp cells indicating a novel mechanism of its anti-cancer effects.
Keywords: carcinogenesis, 4T1 cells, Ruk/CIN85, VPA
Full text: (PDF, in English)

References

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