Biopolym. Cell. 1988; 4(2):105-107.
Short Communications
Stimulation of RNA synthesis by dimethylsulphoxide depends on the developmental stage of the transformed cells culture
- Research Institute of Experimental and Clinical Medicine, Ministry of Public Health, Latvian SSR
Riga, USSR
Abstract
The work has been carried out by the method of quantitative pulse 3H-uridine autoradio-graphy on the line 4/21 of transformed hamster fibroblasts. As previously stated on Zaj-dela ascite hepatoma 2 h treatment with 1 % DMSO causes 2-3-fold enhancing of RNA synthesis. However, it manifests only on 24 h culture with the low ground level of RNA synthesis. The later cultures with the high RNA-synthetic activity do not respond. The trigger-like mechanism of DMSO action is discussed.
Full text: (PDF, in Russian)
References
[1]
Scher W, Friend C. Breakage of DNA and alterations in folded genomes by inducers of differentiation in Friend erythroleukemic cells. Cancer Res. 1978;38(3):841-9.
[2]
Erenpreiss EA, Zirne RA, Erenpreiss YaG. Effect of dimethyl sulfoxide on the ultrastructure of cells Zajdel hepatoma. Tsitologiia. 1984; 26(9):1085.
[3]
Erenpreiss EA, Syakste TG, Zirne RA. Influence of DNA single-strand breaks on the ultrastructure and RNA synthetic activity of chromatin of tumor cells: Proc. IX All-Union symp. "Structure and function of the cell nucleus." Chernogolovka, 1987; 99.
[4]
Hagemann RF. Effect of dimethyl sulfoxide on RNA synthesis in S-180 tumor cells. Experientia. 1969;25(12):1298-300.
[5]
Vasil'ev IuM. Tumor cells and their microenvironment. Vopr Onkol. 1984;30(2):96-103.
[6]
Bolund L, Darzynkiewicz Z, Ringertz NR. Cell concentration and the staining properties of nuclear deoxyribonucleoprotein. Exp Cell Res. 1970;62(1):76-89.
[7]
Reeves R, Cserjesi P. Sodium butyrate induces new gene expression in Friend erythroleukemic cells. J Biol Chem. 1979;254(10):4283-90.
