Biopolym. Cell. 1988; 4(1):15-20.
Structure and Function of Biopolymers
Inversion of the relative stability of AT- and GC-pairs in DNA induced by adsorption of ligands
- Institute of Bioorganic Chemistry, Academy of Sciences of the Byelorussian SSR
The inversion of relative stability of AT- and GC-pairs of bases in the complexes of a block sequence DNA with long-range interacting ligands and DNA with random sequence of pairs of bases with contactly interacting ligands has been theoretically studied. Both types of ligand interaction with DNA are shown to give rise to a nonlinearity of the GC-content dependence of the melting temperature (Tm(x)), which induces a considerable increase in the melting range width (ΔT) at the inversion point. It is found that only short noninteracting ligands which are bound stronger to the boundaries between the helix and coil regions cause both the growth of ΔT at the inversion point and a linearity of the Tm (x) dependence.
Full text: (PDF, in Russian)
 Voskoboinik AD, Monaselidze DR, Mgeladze GN, Chanchalashvili ZI, Lazurkin IuS, Frank-kamenetskii IM. Study of DNA melting in the region of the inversion of relative stability of AT and GC pairs. Mol Biol (Mosk). 1975;9(5):783-90.
 Belintsev BN, Vologodskii AV, Frank-Kamenetskii MD. Influence of base sequence on the stability of the double helix of DNA. Mol Biol (Mosk). 1976;10(4):629-33.
 Akhrem AA, Lando DIu. Effect of selectively reacting ligands on the helix-coil transition of DNA. III. Calculation of the melting curves of DNA-ligand complexes. Mol Biol (Mosk). 1981;15(5):1083-92.
 Lando DYu, Shpakovskiy AG, Akhrem AA. The effect of long-range interactions between adsorbed ligands on the DNA helix-coil transition. Vestsi Akad nauk Bel. SSR. Ser. Khim. Nauk. 1984; 5:21-3.
 Akhrem AA, Fridman AS, Lando DYu. Theory of helix-coil transition of the heterogeneous DNA-heteroqeneous ligands complexes. Biopolym. Cell. 1985; 1(4):171-9.
 Lando DIu, Kul'ba AM, Akhrem AA. Effect of selectively reacting ligands on the helix-coil transition of DNA. IV. Heat denaturation of DNA in an acid medium. Mol Biol (Mosk). 1981;15(5):1093-1101.
 Lando DYu, Friedman AS. Cooperative contact interaction between the ligands adsorbed on DNA, causes a decrease in the width of the melting range. Thes. of reports. V All-Union conf. on spectroscopy for biopolymers. Kharkiv, 1984; 251.
 Tachibana H, Wada A. Ligand-induced melting reaction of specific-sequence DNA molecules. Biopolymers. 1982;21(9):1873-85.
 Lyubchenko YL, Frank-Kamenetskii MD, Vologodskii AV, Lazurkin YS, Gause GG Jr. Fine structure of DNA melting curves. Biopolymers. 1976;15(6):1019-36.
 Raukas E, R?im T. Thermal denaturation of distamycin A--DNA complexes as followed by hyperchromic spectra. Biophys Chem. 1980;11(2):233-7.
 Blagoi IuP, Sorokin VA, Valeev VA, Gladchenko GO. Characteristics of the spiral sphere transition in DNA in a region of inversion of the relative stability of GC- and AT-pairs caused by Cu2+ and Mn2+ ions. Dokl Akad Nauk SSSR. 1978;240(2):459-62.
 Melchior WB Jr, Von Hippel PH. Alteration of the relative stability of dA-dT and dG-dC base pairs in DNA. Proc Natl Acad Sci U S A. 1973;70(2):298-302.
 Record MT Jr, Woodbury CP, Inman RB. Characterization of rodlike RNA fragments. Biopolymers. 1975;14(2):393-408.
 Woodbury CP, Record MT. A range of G+C-independent denaturation solvents for DNA. Biopolymers 1975; 14(11):2417-20.
 Monaselidze DR, Mgeladze GN. Thermal properties of DNA and polydeoxyribonucleotides in a wide range of ionic concentration of neutral salts and a polymer. Biofizika. 1977;22(5):950-8. Russian.
 Shapiro JT, Stannard BS, Felsenfeld G. The binding of small cations to deoxyribonucleic acid. Nucleotide specificity. Biochemistry. 1969;8(8):3233-41.
 Gabrielian AG. Conformational transitions of DNA in concentrated neutral salt solutions. Biofizika. 1979;24(4):620-32.