Biopolym. Cell. 2023; 39(3):161-169.
Key models and theories of carcinogenesis
1Gerashchenko G. V., 1Kashuba V. I., 1Tukalo M. A.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143


A brief overview of the most well-known seven types of carcinogenesis models is presented. They include mutation models, genomic instability models, non-genotoxic models, Darwinian models, tissue organization models, inflammation models, and an integrated model. Each model has specific oncogenic factors that cause certain types of cancer, have their own mechanisms, and are based on certain mathematical models.
Keywords: carcinogenesis, models and hypothesis, oncogenic factors, molecular mechanisms, genetic and epigenetic alterations, mutations, tumor microenvironment


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