Biopolym. Cell. 2021; 37(4):247-258.
Reviews
Microbial biofilms and some aspects of anti-inflammatory drug use
1Rumynska T. M., 1Hural A. R., 1Konechnyi Y. T., 2Vynnytska R. B., 1Lozynskyi A. V., 3Salyha Y. T., 1Korniychuk O. P., 1, 4R.B. Lesyk
  1. Danylo Halytsky Lviv National Medical University
    69, Pekarska Str., Lviv, Ukraine, 79010
  2. Ivano-Frankivsk National Medical Universitу
    2, Halytska Str., Ivano-Frankivsk, Ukraine, 76018
  3. Institute of Animal Biology, NAAS of Ukraine
    38, Stusa Str., Lviv, Ukraine, 79034
  4. University of Information Technology and Management in Rzeszow
    2, Sucharskiego Str., Rzeszow, Poland, 35-225

Abstract

The review presents literature data on the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the formation of bacterial biofilms. The role of biofilm structures as a factor of virulence of microorganisms is shown, and the protective reactions of a macroorganism in infectious processes caused by bacteria — producers of biofilms are characterized. The article also provides the examples of methods for studying biofilm formation and strategies for managing this process. The prospects of further study of the complex interaction between bacterial pathogens in biofilms are shown, which may help to develop further therapeutic strategies against the biofilm-dependent infections.
Keywords: NSAIDs, microbiota, dysbiosis, prostanoids, cyclooxygenase, biofilms

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