Changes in the human placental transcriptome during the physiological course of pregnancy

Lykhenko, O. K.; Frolova, A. O.; Obolenskaya, M. Yu.

doi:10.7124/bc.000A4D

Biopolym. Cell. 2021; 37(1):73-82.

http://dx.doi.org/10.7124/bc.000A4D

Bioinformatics

Changes in the human placental transcriptome during the physiological course of pregnancy

1Lykhenko O. K., 1Frolova A. O., 1Obolenskaya M. Yu.

Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143

Abstract

Aim. To determine the changes of gene expression in human placenta during the physiological course of pregnancy. Methods. The integrative analysis of publicly available data. Results. We have revealed that between the first and second trimesters of gestation the main changes relate to immune processes, morphogenesis and intercellular communication through the surface receptors of the cellular membrane. In the interval between the second and third trimesters, the main changes concern the regulation of the response to external stimuli, metabolic processes, morphogenesis of individual tissues, regulation of signaling pathways via transmembrane serine / threonine protein kinase receptors. Conclusion. The changes in gene expression in human placenta in the course of physiological gestation will serve as a reliable control with the changes during the pathological course of gestation.

Keywords: human placenta, transcriptome, integrative analysis

Full text: (PDF, in English)

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