Biopolym. Cell. 2019; 35(1):16-20.
http://dx.doi.org/10.7124/bc.000996
Structure and Function of Biopolymers
Aggregation of erythrocytes: a novel activity of HBD-2
1Semeniuk D. O., 1Starenka I. O., 2Pogribna A. P., 3Sokol I. V., 3Govsieiev D. O.
  1. Educational and Scientific Center "Institute of Biology and Medicine",
    Taras Shevchenko National University of Kyiv
    64/13, Volodymyrska Str., Kyiv, Ukraine, 01601
  2. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143
  3. Kyiv city maternity hospital N 5
    2, Lobanovskiy Ave., Kyiv, Ukraine, 02000

Abstract

Aim. To investigate an ability of HBD-2 to induce aggregation of erythrocytes. Methods. Aggregation assay, turbidimetry, light microscopy. Results. We have identified aggregation of erythrocytes in presence of at least 12.5 μM of HBD-2 that was confirmed by light microscopy. Effect was depended on HBD-2 concentration and diminished in presence of NaCl. Conclusions. HBD-2 can induce salt-sensitive aggregation of erythrocytes in dose-dependent manner.
Keywords: β-defenins, dose-dependent, salt-sensitive
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