Biopolym. Cell. 2016; 32(6):409-417.
http://dx.doi.org/10.7124/bc.000937
Reviews
A potential role of hydrogen sulfide (H2S) in the regulation of the Ras-ERK signaling-dependent transcription of DNA methyltransferases
1Nikitina T. A.
  1. Oles Honchar Dnipropetrovsk National University
    72, Gagarin Av., Dnipropetrovs'k, Ukraine, 49050

Abstract

Ras-ERK cell signaling regulates transcription of DNA methyltransferases (DNMTs). A role of H2S in regulation of the Ras-ERK signaling activity and DNMTs expression has also been shown. Here we propose a hypothesis that H2S regulates the Ras-ERK signaling-dependent DNMTs transcription. Oxidative stress, lipid metabolism, protein sulfhydration, nitrosylation and nitration are the main targets of regulation by H2S. These cell processes are important for the post-translational modifications (PTMs) of the Ras-ERK signaling pathway enzymes. We provide evidence for the dependence of DNMTs transcription on the PTMs of the enzymes of Ras-ERK signaling pathway regulated by H2S.
Keywords: Ras-ERK cell signaling, DNA methyltransferases, H2S
Full text: (PDF, in English)

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