Biopolym. Cell. 2016; 32(2):98-104.
Extracellular annexins in hemostasis system
1Zhernossekov D. D., 1Roka-Moiia Y. M., 1Grinenko T. V.
  1. Palladin Institute of Biochemistry, NAS of Ukraine
    9, Leontovycha Str., Kyiv, Ukraine, 01601


Annexins are calcium-binding proteins that interact with cellular membranes due to their ability to bind phospholipids. The structural and functional peculiarities of these proteins have been described. Being cytosolic proteins, annexins also possess extracellular activities. However, there are some controversial opinions concerning the functional role of extracellular annexins in the human hemostasis system. We have made an attempt to summarize the latest data and consider some ideas of possible annexin application in medical practice.
Keywords: annexins, hemostasis, plasminogen/plasmin system


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