Biopolym. Cell. 2013; 29(5):428-440.
http://dx.doi.org/10.7124/bc.000835
Discussions
The concept of «origin» – problem definition and attempt of analysis
1Kordium V. A., 2Shuvalova N. S.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. State Organization of Genetic and Regenerative Medicine NAMS Ukraine
    67, Vyshhorodska Str., Kyiv, Ukraine, 04114

Abstract

The present article analyzes the problem of «origin»by the example of respiration. The «origin» implies the system of molecular sensor and affecting signal, which start the chain (cascade) of molecular conversions, leading to the phenotypic changes. As «origin» the most studied elements of the cascade are chosen: molecular oxygen, PHD and HIF protein families and molecules interacting directly with them. The alternative and additional systems are also considered. The important point of the whole regulation is the absence of signaling systems for increasing molecular oxygen concentration (above necessary, i. e. hyperoxia) in the cell.
Keywords: PHD and HIF protein, signaling systems, molecular oxygen
Full text: (PDF, in Russian)

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