Biopolym. Cell. 2013; 29(4):261-265.
http://dx.doi.org/10.7124/bc.000820
Reviews
Molecular genetic biotechnologies – the way to the welfare of the people and increasing of agriculture profitability
1, 2Potopalsky A. I., 1, 2Bolsunova O. I., 1, 2Zaika L. A.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. Institute of Health Promotion and Rebirth of People of Ukraine
    150, Akademika Zabolotnogo Str., Kyiv, Ukraine, 03680

Abstract

We have designed and offered a comprehensive approach to solving several problems in modern agriculture and human health. It is based on the original use of biotechnology. The mechanisms of alkylation of amines, nucleic acids and their derivatives by etylenimin components have been investigated. Alkylation products were purified and characterized, their biological activity, studied in various systems, was identified as well as their antitumor, antiviral and immunomodulatory effects. Based on the development of original methods of natural substances modification and the use of obtained products for the regulation of molecular biological processes a new scientific direction has been created. This article presents the results of over 50-years-old research on development of original biotechnological methods.
Keywords: modification, natural substances, amitozyn, izatizon, new varieties, biotechnologies
Full text: (PDF, in English)

References

[1] Potopalsky A. I., Petlychnaya L. I., Yvasyvka S. V. Modification of berberin alkaloids Kyiv: Naukova Dumka, 1980 109 p.
[2] Potopalsky A. I. Amitozyn action on experimental malignant tumors in rats Oncology Questions: Proc. of Scientific Medical Students Societies of Medical Intitutions of RSFSR (Moscow, 9–12 April 1963) Moscow, 1963:
[3] Potopalsky A. I. Some data about the treatment of malignant tumors in the experiment XXXI Conf. of Student Scientific Society (14–15 December 1961 Stanislav's State Medical Institute) Stanislav, 1961:36–37.
[4] Potopalsky A. I. Celandine preparations in biology and medicine Kyiv: Naukova Dumka, 1992 200 p.
[5] Herman B., Gudrun A., Potopalsky A. I., Chroboczek J., Tcherniuk S. O. Amitozyn impairs chromosome segregation and induces apoptosis via mitotic checkpoint activation PLoS One 2013 8, N 3 e57461.
[6] Potopalsky A. I., Lozyuk L. V., Mirolyubova A. N., Bessarabov B. F. The antiviral, anticancer and antileukemia drug izatizon Kyiv: Naukova Dumka, 1991 191 p.
[7] Lozyuk L. V., Potopalsky A. I., Lozyuk R. M. Medical treatment and prevention of viral diseases Lviv: Norma, 2003 208 p.
[8] Potyahaylo A. L., Bolsunova O. I., Zayika L. A., Potopal'sky A. I., Hovorun D. M. Conformational analysis of metysazon molecule: semi-empirical quantum chemical data Biopolym. Cell 2003 19, N 3:292–294
[9] Potyahaylo A. L., Bolsunova O. I., Zayika L. A., Potopalsky A. I. Prototropic tautomerism, proton acceptor and proton donor properties of isatin: quantum chemical calculation data Biopolym. Cell 2003 19, N 2:202–204.
[10] Zaika L. A., Bolsunova O. I., Patskovsky Yu. V., Rubashevsky E. L., Diadiun S. T., Ribalco S. L., Potopalsky A. I. The antiviral drug izatizon possesses no mutagenic action and stimulates proliferation of cells of immune system Biopolym. Cell 1995 11, N 6:89–95.
[11] Zaika L. A., Bolsunova O. I., Potopalsky A. I. Antiviral, anticancer and immunomodulatory properties of IZATIZON therapeutic drug.–Kyiv: Kolobig, 2010.–212 p.
[12] Potopalsky A. I., Jurkiewicz L. N. Third Millennium – new plants for health, wellbeing, beauty and longevity Kyiv: Kolobig, 2005 168 p.
[13] Katsan V. A., Potopalsky A. I. Features of action of exogenous DNA preparations in obtaining some new forms of tobacco Kyiv: Kolobig, 2007 176 p.