Biopolym. Cell. 2012; 28(4):288-291.
Minireviews
Miniature as a hypothetical regulatory protein of the Bursicon/Rickets signaling cascade in the wing epithelia of Drosophila melanogaster
1, 3Bilousov O. O., 1, 2Katanaev V. L., 3Kozeretska I. A.
  1. Department of Pharmacology and Toxicology, University of Lausanne
    27, Bugnon Str., CH-1005 Lausanne, Switzerland
  2. Institute of Protein Research, Russian Academy of Sciences
    Pushchino, Moscow Region, Russian Federation, 142290
  3. Educational and Scientific Center "Institute of Biology",
    Taras Shevchenko National University of Kyiv
    64/13, Volodymyrska Str., Kyiv, Ukraine, 01601

Abstract

Soon after eclosion, epithelial cells of the Drosophila wing undergo a number of the processes due to a release of the neurohormone bursicon and its further binding to the GPCR Rickets, collectively referred to as wing maturation. Here we propose hypothetical models of the interaction between extracellular Miniature, and also Dusky, proteins and proteins responsible for triggering of the wing maturation processes in Drosophila melanogaster.
Keywords: bursicon, Rickets, Miniature, Dusky, wing maturation

References

[1] Honegger H. W., Dewey E. M., Ewer J. Bursicon, the tanning hormone of insects: recent advances following the discovery of its molecular identity J. Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol 2008 194, N 12:989–1005.
[2] Kimura K., Kodama A., Hayasaka Y., Ohta T. Activation of the cAMP/PKA signaling pathway is required for post-ecdysial cell death in wing epidermal cells of Drosophila melanogaster Development 2004 131, N 7:1597–1606.
[3] Natzle J. E., Kiger J. A. Jr., Green M. M. Bursicon signaling mutations separate the epithelial-mesenchymal transition from programmed cell death during Drosophila melanogaster wing maturation Genetics 2008 180, N 2:885–893.
[4] Togel M., Pass G., Paululat A. The Drosophila wing hearts originate from pericardial cells and are essential for wing maturation Dev. Biol 2008 318, N 1:29–37.
[5] Johnson S. A., Milner M. J. The final stages of wing development in Drosophila melanogaster Tissue Cell 1987 19, N 4:505–513.
[6] Luo C. W., Dewey E. M., Sudo S., Ewer J., Hsu S. Y., Honegger H. W., Hsueh A. J. W. Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2 Proc. Natl Acad. Sci. USA 2005 102, N 8:2820–2825.
[7] Van Loy T., Vandersmissen H. P., Van Hiel M. B., Poels J., Verlinden H., Badisco L., Vassart G., Vanden Broeck J. Comparative genomics of leucine-rich repeats containing G protein-coupled receptors and their ligands Gen. Comp. Endocrinol 2008 155, N 1:14–21.
[8] Roch F., Alonso C. R., Akam M. Drosophila miniature and dusky encode ZP proteins required for cytoskeletal reorganisation during wing morphogenesis J. Cell Sci 2003 116, Pt 7:1199– 1207.
[9] Jovine L., Darie C. C., Litscher E. S., Wassarman P. M. Zona pellucida domain proteins Annu. Rev. Biochem 2005 74:83–114.
[10] Zhuk O. W. Kozeretska I. A., Sivolob A. V. Min-like protein of Drosophila virilis and its mutant forms: primary structure and possible functional role Biopolym. Cell 2008 24, N 4:286–293.
[11] Hynes R. O. The extracellular matrix: not just pretty fibrils Science 2009 326, N 5957:1216–1219.
[12] Baker J. D., Truman J. W. Mutations in the Drosophila glycoprotein hormone receptor, rickets, eliminate neuropeptide-induced tanning and selectively block a stereotyped behavioral program J. Exp. Biol 2002 205, Pt 17:2555–2565.
[13] Gilman A. G. G proteins: transducers of receptor-generated signals Annu. Rev. Biochem 1987 56–P. 615–649.
[14] Katanayeva N., Kopein D., Portmann R., Hess D., Katanaev V. L. Competing activities of heterotrimeric G proteins in Drosophila wing maturation PloS One 2010 5, N 8 e12331.
[15] Brower D. L., Jaffe S. M. Requirement for integrins during Drosophila wing development Nature 1989 342, N 6247:285– 287.
[16] Kiger J. A. Jr, Natzle J. E., Kimbrell D. A., Paddy M. R., Kleinhesselink K., Green M. M. Tissue remodeling during maturation of the Drosophila wing Dev. Biol 2007 301, N 1:178–191.
[17] Dobzhansky Th. The influence of the quantity and quality of chromosomal material on the size of the cells in Drosophila melanogaster Dev. Genes Evol 1929 115, N 3:363–379.
[18] Newby L. M., White L., DiBartolomeis S. M., Walker B. J., Dowse H. B., Ringo J. M., Khuda N., Jackson F. R. Mutational analysis of the Drosophila miniature-dusky (m-dy) locus: effects on cell size and circadian rhythms Genetics 1991 128, N 3:571–582.
[19] Kozeretska I. A., Gubenko I. S., Gorb S. N. New unusual miniature-like wing mutation in Drosophila virilis J. Morphol 2004 261, N 3:270–275.
[20] Bilousov O. O., Kozeretska I. A., Katanaev V. L. Role of the gene Miniature in Drosophila wing maturation genesis 2012. 50, Issue 7, pages 525–533
[21] Wang X., Harris R. E., Bayston L. J., Ashe H. L. Type IV collagens regulate BMP signalling in Drosophila Nature 2008 455, N 7209:72–77.
[22] Malanchi I., Santamaria-Martinez A., Susanto E., Peng H., Lehr H. A., Delaloye J. F., Huelsken J. Interactions between cancer stem cells and their niche govern metastatic colonization Nature 2012 481, N 7379:85–89.