Biopolym. Cell. 2012; 28(4):281-284 .
The SEA complex – the beginning
1Algret R., 1Dokudovskaya S. S.
  1. Institut Gustave Roussy
    114, rue Edouard Vaillant, Villejuif, France, 94805


The presence of distinctive internal membrane compartments, dynamically connected via selective transport pathways, is a hallmark of eukaryotic cells. Many of the proteins required for formation and maintenance of these compartments share an evolutionary history. We have recently identified a new conserved protein complex – the SEA complex – that possesses proteins with structural characteristics similar to the membrane coating complexes such as the nuclear pore complex (NPC), the COPII vesicle coating complex and HOPS/CORVET tethering complexes. The SEA complex in yeast is dynamically associated to the vacuole. The data on the function of the SEA complex remain extremely limited. Here we will discuss a possible role of the SEA complex based on the data from genetic assays and a number of functional studies in both yeast and other eukaryotes.
Keywords: Saccharomyces cerevisiae, the SEA complex, vacuoles


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