Biopolym. Cell. 2012; 28(1):56-61.
http://dx.doi.org/10.7124/bc.00002D
Molecular Biomedicine
The influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients
1Kriachok I. A., 1Khranovska N. M., 1Svergun N. M., 1Filonenko K. S., 1Novosad O. I., 1Titorenko I. B., 1Martynchik A. V., 1Gubareva H. O., 1Kadnikova T. V., 1Aleksik O. M., 1Kushchevyy E. V., 1Pastushenko I. V.
  1. National Cancer Institute
    33/43, Lomonosova Str., Kyiv, Ukraine, 03022

Abstract

The aim of this research was to study the influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients. Methods. The polymorphic variants of GSTP1 gene were analyzed using Allelic Discrimination Real-Time PCR. Results. The GSTP1 polymorphism is not directly involved in the development of Hodgkin’s lymphoma and chemotherapy-related toxicity, but homozygous wild genotype of this gene is associated with a worse clinical response to the therapy and a higher risk of relapse. Conclusions. The investigation of GSTP1 polymorphism is very promising, since it might provide a possible application of this genetic marker as an independent prognostic factor of Hodgkin’s lymphoma.
Keywords: Hodgkin’s lymphoma, polymorphism, GSTP1 gene
Full text: (PDF, in English)

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