Biopolym. Cell. 2011; 27(5):373-376.
http://dx.doi.org/10.7124/bc.000126
Results on complex treatment of patients with glial tumors of brain with local chemotherapy
1Harutyunyan L. R.
  1. National Center of Oncology named after V. A. Fanarjyan, MH of Republic of Armenia
    76, Fanarjyan Str., Yerevan, Republic of Armenia, 0052

Abstract

Aim. For the purpose of local chemotherapy in patients with malignant brain tumors after partial or total removal of tumors we used biodegradable film with methotrexate. The film, due to its properties, is firmly attached to the wound surface. With its composition of chemotherapeutic agents over specified time, the dosed film immediately affects diseased tissue, playing the role of a local chemotherapy depo. Methods. Results of treatment of 74 patients with low differentiated gliomas of the brain, which have undergone a comprehensive treatment that includes surgical removal of tumor and implantation of methotrexate depo in the wall of postoperative cerebral injury followed by radiotherapy in the pig on a bed of the tumor removed. Results. A retrospective analysis of the results of complex treatment of patients with glial brain tumors with local chemotherapy showed a significant increase in disease-free period in patients who have undergone, consistently, surgery, chemotherapy and adjuvant local radiation therapy. Conclusions. Our research has shown that the use of local chemotherapy greatly improves the results of treatment of patients not only for total removal of intracerebral tumors, but also for subtotal removal, as well as in patients with prolonged tumor growth, when there is no possibility of radiation treatment.
Keywords: glial tumors, local chemotherapy, methotrexate, polymeric film
Full text: (PDF, in English)

References

[1] Konstantinova M. M. Sovremennoye sostoyaniye i perspektivy khimioterapii zlokachestvennykh opukholey golovnogo mozga Sovremennaya Onkologiya 2002 4, N 3 P. 144–149.
[2] Kolosov A. E., Koshchug S. D., Mel'nikov R. A. Sovremennaya klassifikatsiya opukholey (gistologicheskaya, tsitologicheskaya, klinicheskaya) Kishinev: Shtiintsa, 1990 P. 152–156.
[3] Romodanov A. P., Sosnov Yu. D. Method of regional and local chemotherapy in treatment of malignant tumors of the brain Vestn. Akad. med. nauk SSSR 1974 29, N 11 P. 83–86.
[4] Boiardi A., Salmaggi A., Pozzi A., Broggi G., Silvani A. Interstitial chemotherapy with mitoxantrone in recurrent malignant glioma: preliminary data J. Neurooncol 1996 27, N 2 P. 157162.
[5] Brem H., Ewend M. G., Piantadosi S., Greenhoot J., Burger P. C., Sisti M. The safety of interstitial chemotherapy with BCNUloaded polymer followed by radiation therapy in the treatment of newly diagnosed malignant gliomas: phase I trial J. Neurooncol 1995 26, N 2 P. 111-123.
[6] Olivi A., Barker F., Tatter S., Bruce J., Judy K., Engelhard H., Burak E., Hilt D., Grossman S., Joy F., Piantadosi S. Toxicity and pharmacokinetics of interstitial BCNU administered via wafers: results of a phase i study in patients with recurrent malignant glioma Abstr. of Annual Meeting of the American Society of Clinical Oncology 1999 P. 143a.
[7] Kong Q., Kleinschmidt-Demasters B. K., Lillehei K. O. Intralesionally implanted cisplatin cures primary brain tumor in rats J. Surg. Oncol 1997 64, N 4 P. 268-273.