Biopolym. Cell. 2011; 27(4):249-257.
Molecular mechanisms of development of cellular insulin resistance
1Raksha N. G., 1Savchuk O. M., 1Ostapchenko L. I.
  1. Educational and Scientific Center "Institute of Biology",
    Taras Shevchenko National University of Kyiv
    64/13, Volodymyrska Str., Kyiv, Ukraine, 01601


Some of the pathogenetic mechanisms which cause the state of cellular insulin resistance on receptor and postreceptor levels were analyzed. Special attention is given to the analysis of factors which influence the activity of the components of phosphatidylinositol chain of insulin signaling cascade.
Keywords: insulin resistance, insulin receptor substrates, phosphatidylinositol-3-kinase, serine phosphorylation


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