Biopolym. Cell. 2010; 26(2):97-104.
Vitamin D – a novel role in pregnancy
1, 2Arora Chander P., 1, 2Hobel C. J.
  1. Cedars-Sinai Medical Center,
    Burns-Allen Research Institute and the Division of Maternal-Fetal Medicine
    8635, West Third St., Ste 160W, Los Angeles, CA, USA, 90048
  2. David Geffen School of Medicine,
    University of California Los Angeles
    10833, Le Conte Avenue, Los Angeles, CA, USA, 90095


Vitamin D regulates placental development and function. It is a potent regulator of the immune system- stimulating antimicrobial responses while suppressing inflammation. Its deficiency has been linked to increased risk of serious chronic and inflammatory diseases. Vitamin D deficiency during pregnancy increases susceptibility to infection and inflammation, leading, in turn, to outcome like preterm birth or preeclampsia. Pregnant women with darker skin pigmentation are more likely to be vitamin D deficient, particularly when living in regions with low exposure to sunlight. It is possible that during pregnancy, a primary non-infectious inflammatory process is activated by vitamin D deficiency. Combined assessment of vitamin D deficiency and inflammatory markers in early pregnancy or during different stages of pregnancy may facilitate the recognition of the risk of complications.
Keywords: vitamin D, pregnancy, immune response


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