Biopolym. Cell. 2009; 25(5):390-397.
http://dx.doi.org/10.7124/bc.0007F1
Molecular Biophysics
Semi-quantitative model of the gating of KcsA ion channel. 1. Geometry and energetics of the gating
1Kharkyanen V. N., 1Yesylevskyy S. O., 1Berezetskaya N. M., 2Boiteux C., 2Ramseyer Ch.
  1. Institute of Physics, NAS of Ukraine
    46, Prospect Nauki, Kyiv, Ukraine, 03028
  2. UMR CNRS 6624, Faculte des Sciences et Techniques, Universite de Franche-Comte
    16 route de Gray, La Bouloie, 25030 Besancon Cedex, France

Abstract

The aim of this series of papers is to develop the semi-quantitative theory of the gating of KcsA channel. For this purpose the available structural and electrophysiological data and the results of molecular dynamics simulations were used in the context of the concept of dynamical self-organization. In the first paper we describe the simplified model of the geometry and energetics of the gating process. This work is the first successful attempt of combining the structure and dynamics of a real protein and the general concept of dynamic self-organization.
Keywords: ion channel, KcsA channel, dynamic self-organization, channel gating
Full text: (PDF, in English)

References

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