Biopolym. Cell. 2009; 25(1):50-55.
Viruses and Cell
Analysis of molecular features of the Ukrainian isolates of HIV-1
1Pukish N. S., 2Shcherbinska A. M., 2Babij N. O., 1Polishchuk V. P.
- Taras Shevchenko National University of Kyiv
64, Volodymyrska Str., Kyiv, Ukraine, 01601 - Ukrainian Center for AIDS Prevention of the Ministry of Health of Ukraine
5 Mykola Amosov str, Kyiv, Ukraine, 03038
Abstract
Analysis of HIV-1 genome in the region of pol gene was performed by sequencing virus genome using 64 samples of blood from HIV-infected persons. Subtype a HIV-1 revealed to be dominating among investigated samples and a great number of samples belonged to a circulating recombinant forms of HIV-1. Analysis of mutations showed only one mutation connected with development of HIV-1 resistance to antiretroviral treatment. Most samples included polymorphic substitutions of nucleotides in the virus genome region studied.
Keywords: human immunodeficiency virus 1, polymorphic substitutions, resistance mutations, recombinant forms of HIV-1, subtype of HIV-1
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