Biopolym. Cell. 2009; 25(1):50-55.
http://dx.doi.org/10.7124/bc.0007CA
Viruses and Cell
Analysis of molecular features of the Ukrainian isolates of HIV-1
1Pukish N. S., 2Shcherbinska A. M., 2Babij N. O., 1Polishchuk V. P.
  1. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01601
  2. Ukrainian Center for AIDS Prevention of the Ministry of Health of Ukraine
    5 Mykola Amosov str, Kyiv, Ukraine, 03038

Abstract

Analysis of HIV-1 genome in the region of pol gene was performed by sequencing virus genome using 64 samples of blood from HIV-infected persons. Subtype a HIV-1 revealed to be dominating among investigated samples and a great number of samples belonged to a circulating recombinant forms of HIV-1. Analysis of mutations showed only one mutation connected with development of HIV-1 resistance to antiretroviral treatment. Most samples included polymorphic substitutions of nucleotides in the virus genome region studied.
Keywords: human immunodeficiency virus 1, polymorphic substitutions, resistance mutations, recombinant forms of HIV-1, subtype of HIV-1
Full text: (PDF, in English) (PDF, in Ukrainian)

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