Biopolym. Cell. 2009; 25(1):12-26.
http://dx.doi.org/10.7124/bc.0007C6
Reviews
Recombination in immunoglobulin gene loci
1Halytskiy V. A., 1Komisarenko S. V.
  1. Palladin Institute of Biochemistry, NAS of Ukraine
    9, Leontovycha Str., Kyiv, Ukraine, 01601

Abstract

Gene network of the lymphoid cell differentiation coordinates precisely the recombination process in immunoglobulin gene loci. In our opinion, cellular microRNAs can contribute to the allelic exclusion through microRNA-directed DNA methylation and participate in retargeting recombinases activity from the gene loci of heavy immunoglobulin chains to the gene loci of light chains .
Keywords: immunoglobulin gene locus, recombination, microRNA, allelic exclusion
Full text: (PDF, in Ukrainian)

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