Biopolym. Cell. 2008; 24(5):406-411.
Bioorganic Chemistry
Tricyclic 1,2,4-triazine bearing heterosystem: directed synthesis of new bioactive compounds
- Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
Abstract
A new series of tricyclic heteroaromatic compounds was prepared by cyclization of the 2N-substituted-6-bromo-3-oxo(amino)-1,2,4- triazin-5(4H)-ones with 2-aminobenzothiol. The structure of bioactive tricyclic glycosides, obtained earlier by the simplified silylic method, is confirmed, as well as expedience and adequacy of this method for directed glycosylation of the triazine bearing tricyclic bases.
Keywords: condensed 1,2,4-triazine, tricyclic nucleoside analogues
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