Biopolym. Cell. 2008; 24(1):78-81.
http://dx.doi.org/10.7124/bc.000793
Short Communications
Influence of human apolipoprotein A-1 transgene injection on level of cholesterol and morphology of tissues of rabbits on cholesterol diet
1Gilchuk Iu. M., 1Toporova O. K., 2Novikova S. M., 1Kordium V. A.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. Gerontology Institute of the Academy of Medical Sciences of Ukraine
    67, Vyshgorodska Str., Kyiv, Ukraine, 04114

Abstract

It has been shown that repetitive injection of plasmid DNA, containing human apolipoprotein A-1 (apoA-1) gene, in the complex with polyethylenimine into the liver parenchyma of cholesterol-rich diet rabbits influenced cholesterol concentration in animal blood and liver and morphology of vessel tissues. Thus, apoA-1 injected animals were shown not to reveal the increase in total cholesterol concentration in blood and morphology alteration of liver and vessel tissues, specific for atherosclerosis in cholesterol-fed rabbits. The data obtained reveal that human apoA-1 transgene injection might suppress experimental atherosclerosis in cholesterol-fed rabbits.
Keywords: apolipoprotein A-1, atherosclerosis, transgene
Full text: (PDF, in Ukrainian)

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