Biopolym. Cell. 2007; 23(2):108-114.
http://dx.doi.org/10.7124/bc.00075C
Molecular Biomedicine
Impact of inductive and selective agents on biosynthesis of new antistaphylococcal antibiotic batumin
1Churkina L. N., 1Kravets A. N., 1Klochko V. V.
  1. D. K. Zabolotny Institute of Microbiology and Virology, NAS of Ukraine
    154, Academika Zabolotnogo Str., Kyiv, Ukraine, 03680

Abstract

Application of high concentrations of antistaphylococcal antibiotic batumin in order to increase biosynthetic activity of the own strain-producent allowed selecting variants with increased pro­ ductivity. Clone Pseudomonas batumici No. 9 with maximum activity synthesized from 60 to 70 mg of batumin per I of culture medium, which was 2 times higher than the activity of the most productive natural strain-producent However, after storage of this culture in non-selective conditions we noticed gradual decrease in the activity. Chlortetracy dine possesses only selective influence, the result of which was raise in the content of clones with the increased activity in producent's population.
Keywords: batumin, chlortetrасуdine, strain-producent, Staphylococcus aureus
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